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Subject
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Mouse Anti-Human DNA Polymerase, epsilon Ab-1 Mouse Monoclonal Antibody, Biotin Conjugated, Clone 93H3A |
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Description
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0.1 ml, 200 ug/ml / Human, Monkey, Cow, Mouse, D. melanogaster, insect cells, S. cerevisiae, X. laevis/Mouse |
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Clonality
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Mono |
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Company
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Lab Vision |
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Application
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Request Info |
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Conjugation
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Biotin |
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Immunogen
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DNA Polymerase, epsilon |
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Contents
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Polepsilon is present in proliferating cells and is implicated in repair of UV-damaged DNA. It is found to be a component of a recombination complex that is able to repair deletions and double-strand breaks. It is not known whether polepsilon* can replace polepsilon in these processes. Comments: 140kDa form of polepsilon, named polepsilon* is detected only by Ab-1 (directed against aa 1-176) and Ab-2 (directed against aa 242-474) and not by Ab-3 (directed against aa 2095-2257), suggesting that the 140kDa polepsilon* is a truncated from of polepsilon that has lost its C-terminal half.^ ^Ab-1 does not cross-react with DNA polymerase alpha or kappa. It does not neutralize the polymerase or exonuclease activity of the enzyme. |
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