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Description |
Unit |
Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-25-170316 |
GTX12223 |
Mouse Anti-KDEL Monoclonal Antibody, Unconjugated, Clone 10C3/100 ug/This antibody recognizes proteins containing the KDEL sequence in mammals, birds, insects and plants. Cross-reacts with yeast proteins containing the HDEL sequence./Mouse |
1/EA |
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문의 |
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Subject
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Mouse Anti-KDEL Monoclonal Antibody, Unconjugated, Clone 10C3 |
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Description
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100 ug / This antibody recognizes proteins containing the KDEL sequence in mammals, birds, insects and plants. Cross-reacts with yeast proteins containing the HDEL sequence./Mouse |
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Clonality
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Mono |
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Company
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GeneTex |
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Application
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ELISA, ICC, WB |
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Conjugation
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Unconjugated |
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Immunogen
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KDEL |
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Contents
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Mouse monoclonal [10C3] to KDEL - ER Marker
The sequence Lys-Asp-Glu-Leu (KDEL) or a closely related sequence, is present at the carboxy-terminus of soluble endoplasmic reticulum (ER) resident proteins and some membrane proteins. 78 and 94 kDa glucose regulated proteins (GRP 78) and GRP 94 respectively and protein disulfide isomerase (PDI) all share the C-terminal KDEL sequence. The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.
Immunogen: Peptide corresponding to amino acids 649-654 of rat Grp78 conjugated to KLH.
Specificity: This antibody recognizes proteins containing the KDEL sequence in mammals, birds, insects and plants. Cross-reacts with yeast proteins containing the HDEL sequence. |
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