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Description |
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Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-310477 |
NB100-1519 |
Acetylcholinesterase Antibody - Early Neuronal Development//Human/Goat |
1/EA |
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Subject
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Acetylcholinesterase Antibody - Early Neuronal Development |
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Description
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/ Human/Goat |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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ELISA, Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Hu | | Applications: | WB, ELISA | | Clonality: | Polyclonal | | | Gene: | ACHE | | Purity: | Immunogen affinity purified | | Host: | Goat | | | Specificity: | ACHE - Early Neuronal Development | | Publications: | Antibody has not yet been mentioned in a publication. | Details: | Isotype: | IgG | | Immunogen: | Synthetic peptide QFDHYSKQDRCSDL, representing the C-Terminus of the human protein according to NP_000656. | | Marker: | Early Neuronal Development | Gene Symbol: ACHE | Entrez: | 43 (Human) | | | 11423 (Mouse) | | Swiss Prot: | NP_000656. (Human) | | Related Genes: | CHAT, BCHE, CAT, SH2D3C, GLYAT, OP, VIP, TH, TAC1, NGF, G4, NPY, AFP, APP, PNPLA6, ACHR, ACE, DLD, GSTP1, LAMC2, GSTK1, SLCO6A1, SST, CA1, ALB, SLC18A3, NT5E, GFAP, BDNF, POMC, CA3, TRIM26, SOD1, LIPG, CALCA, CHRNA4, A12, S100A12, GPI, GSR | Background: Acetylcholinesterase, or ACHE, hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. Species: | Reactivity: | Human, mouse, cat, rabbit and rat. | Applications: | Uses: | This antibody is useful for Peptide ELISA and Western Blot. Western Blot: Approx 70kDa band observed in Human Brain (Cerebellum) lysates (calculated MW of 67.8kDa according to NP_000656.1). | | Dilutions: | ELISA 1:2000, Western Blot 1-3ug/ml. | | Concentrations: | 0.5 mg/ml | | Positive Controls: | 2 positive controls | Packaging: | Buffer: | Tris-saline containing [pH7.3] with 0.5% BSA | | Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. | | Preservative: | 0.02% Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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