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Description |
Unit |
Price
(VAT별도) |
납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-310449 |
NB100-78589 |
c Abl Antibody//Human, Mouse/Rabbit |
1/EA |
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문의 |
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Subject
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c Abl Antibody |
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Description
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/ Human, Mouse/Rabbit |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Mu, Hu | | Applications: | WB | | Clonality: | Polyclonal | | | Gene: | ABL1 | | Purity: | Immunogen affinity purified | | Host: | Rabbit | | Details: | Isotype: | IgG | | Immunogen: | The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of human c-Abl 1b that contains tyrosine 412. Note: there are two widely expressed forms of c-Abl produced by alternative splicing, designated 1b (the more common form) and 1a. The corresponding phosphorylation site from 1a is tyrosine 393. | | Localization: | Cytoplasmic and Nuclear | Gene Symbol: ABL1 | Entrez: | 25 (Human) | | | 11350 (Mouse) | | Related Genes: | BCR, MTTP, ITGB2, SRC, ITGAL, TP53, ITGAM, MYC, ETV6, CD34, IL3, AKT1, CNTNAP1, KIT, PIK3CG, RUNX1, JAK2, LTBR, CDKN2A, EGFR, BCL2, ITGAX, MLL, BCL2L1, MAPK1, STAT5A, STAT5B, KITLG, PDGFRB, IL2, CDKN1A, PTK2B, EGF, ABI1, GRB2, NOL3, CRK, CR3, JUN, FOS | Background: c-Abl is a 140-150 kDa non-receptor protein tyrosine kinase whose precise functions are not known, but roles for Abl in growth factor and integrin signaling, cell cycle regulation, cytoskeletal reorganization, neurogenesis, and responses to DNA damage and oxidative stress have been suggested. c-Abl kinase activity is increased in vivo by diverse physiological stimuli including ionizing radiation, entry into S phase, integrin activation, and platelet-derived growth factor (PDGF) stimulation. c-Abl contains various protein binding domains that appear to enable it to regulate the functions of many proteins by forming complexes, most notably three isoforms of the oncogenic protein Bcr/Abl. c-Abl becomes fully activated by sequential phosphorylation of tyrosines 412 and 245. Species: | Reactivity: | Cross-reacts with Human. Expected to cross-react with Mouse (100% identity with immunogen) due to sequence homology. Not yet tested in other species. | Applications: | Uses: | WB: Use at a concentration of 0.1 - 1.0 | | Dilutions: | Western Blot | | Concentrations: | 0.5 mg/ml | | Positive Controls: | 1 positive controls | Packaging: | Buffer: | PBS pH 7.3 (without Mg2+ and Ca2+) containing 50% glycerol, 1.0mg/ml BSA (IgG, protease free). . | | Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. | | Preservative: | 0.05% Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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