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Cat. No |
Model |
Description |
Unit |
Price (VATº°µµ) |
³³±â |
Àç°í |
DataSheet |
ÁÖ¹®/°ßÀû |
LCA-23-310450 |
NB100-81828 |
c Abl Antibody//Human, Mouse/Rabbit |
1/EA |
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Subject
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c Abl Antibody |
Description
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/ Human, Mouse/Rabbit |
Clonality
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Poly |
Company
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Novus biologicals |
Application
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IHC-P |
Conjugation
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Immunogen
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Contents
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Description:Summary: Species: | Mu, Hu | Applications: | IHC | Clonality: | Polyclonal | | Gene: | ABL1 | Purity: | Immunogen affinity purified | Host: | Rabbit | | Specificity: | c-Abl (specific to a.a. 412) detects endogenous levels of total c-Abl protein. | Publications: | Antibody has not yet been mentioned in a publication. | Details: Isotype: | IgG | Immunogen: | The antiserum was produced against synthesized non-phosphopeptide derived from human c-Abl around the phosphorylation site of tyrosine 412 (D-T-YP-T-A). | Gene Symbol: ABL1 Entrez: | 25 (Human) | | 11350 (Mouse) | Swiss Prot: | P00519 (Human) | Related Genes: | BCR, MTTP, ITGB2, SRC, ITGAL, TP53, ITGAM, MYC, ETV6, CD34, IL3, AKT1, CNTNAP1, KIT, PIK3CG, RUNX1, JAK2, LTBR, CDKN2A, EGFR, BCL2, ITGAX, MLL, BCL2L1, MAPK1, STAT5A, STAT5B, KITLG, PDGFRB, IL2, CDKN1A, PTK2B, EGF, ABI1, GRB2, NOL3, CRK, CR3, JUN, FOS | Background: The c Abl proto oncogene encodes a protein tyrosine kinase that is located in the cytoplasm and nucleus. In chronic myelogenous leukemia and in a subset of acute lymphoblastic leukemias, the c Abl proto oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome) As the result of the fusion of c Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The molecular consequence of this translocation is the generation of a chimeric Bcr/Abl mRNA encoding activated Abl protein tyrosine kinase. c-Abl is a 140-150 kDa non-receptor protein tyrosine kinase whose precise functions are not known, but roles for Abl in growth factor and integrin signaling, cell cycle regulation, cytoskeletal reorganization, neurogenesis, and responses to DNA damage and oxidative stress have been suggested. c-Abl kinase activity is increased in vivo by diverse physiological stimuli including ionizing radiation, entry into S phase, integrin activation, and platelet-derived growth factor (PDGF) stimulation. c-Abl contains various protein binding domains that appear to enable it to regulate the functions of many proteins by forming complexes, most notably three isoforms of the oncogenic protein Bcr/Abl. c-Abl becomes fully activated by sequential phosphorylation of tyrosines 412 and 245. Species: Reactivity: | Human and Mouse. | Applications: Uses: | Immunohistochemistry | Dilutions: | immunohistochemistry 1:50-1:100 | Concentrations: | 1.0 mg/ml | Positive Controls: | 1 positive controls | Packaging: Buffer: | phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, and 50% glycerol. | Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. | Preservative: | 0.02% Sodium Azide | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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