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Description |
Unit |
Price
(VAT별도) |
납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-310490 |
NB100-66022 |
Acinus Antibody//Human/Rabbit |
1/EA |
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문의 |
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Subject
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Acinus Antibody |
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Description
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/ Human/Rabbit |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Hu | | Applications: | WB | | Clonality: | Polyclonal | | | Gene: | ACIN1 | | Purity: | IgG purified | | Host: | Rabbit | | | Specificity: | NB100-66022 recognises Acinus (apoptosis chromatin condensation inducer in the nucleus), an inducer of chromatin condensation. The recognises a C-terminal region within three splice forms of Acinus, designated Acinus L, Acinus S and Acinus S'. | | Publications: | Antibody has not yet been mentioned in a publication. | Details: | Isotype: | IgG | | Immunogen: | Peptide SRSTPVRDRGGRR corresponding to the C-terminal region of Acinus. | | Epitope: | SRSTPVRDRGGRR | | Localization: | Nuclear | Gene Symbol: ACIN1 | Entrez: | 22985 (Human) | | Related Genes: | NF2, CAT, ALB, EGF, PRDM10, GLUL, CCK, BBS9, CE, GLYAT, GSTP1, INS, PPA1, RRM2, CD1E, CD82, CYCS, PCNA, CASP3, AVP, CDKN1A, PI3, SOD1, AQP5, AKT1, ME1, G6PD, AKR1A1, PCNT, SERPINF2, PLEC1, RP, GGT1, GCG, PCK2, CREB3L1, ME3, ME2, TNF, TP53 | Background: Chromatin condensation and nuclear fragmentation (CCNF) are the hallmarks of apoptosis. CCNF is triggered by the activation of members of the caspase family, caspase activated DNase (CAD/DFF40), and several novel proteins including AIF and CIDE. A new inducer of chromatin condensation was recently identified and designated Acinus (for apoptotic chromatin condensation inducer in the nucleus). Acinus is cleaved by Caspase 3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed. Three different spliced forms of Acinus have been identified in human and mouse and designated Acinus L (1341 amino acids), Acinus S (583 amino acids) and Acinus S' (614 amino acids). Species: | Reactivity: | Human. Not yet tested in other species. | Applications: | Uses: | This antibody is useful for Western Blot | | Dilutions: | Western Blot | | Concentrations: | 0.5 mg/ml | Packaging: | Buffer: | Phosphate buffered saline | | Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. | | Preservative: | 0.02% Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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