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Description |
Unit |
Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-310546 |
NB300-549 |
Adenosine A1 Receptor Antibody//Bovine, Human/Rabbit |
1/EA |
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문의 |
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Subject
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Adenosine A1 Receptor Antibody |
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Description
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/ Bovine, Human/Rabbit |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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IHC-P, IP, Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Rt, Hu, Bv | | Applications: | WB, IP, IHC-P | | Clonality: | Polyclonal | | | Gene: | ADORA1 | | Purity: | Affinity purified | | Host: | Rabbit | | | Specificity: | Detects Adenosine Receptor A1. This does not detect other AR subtypes. | | Publications: | Antibody has been mentioned in at least 1 publication. | Details: | Isotype: | IgG | | Immunogen: | Synthetic peptide: CQPKPPIDEDLPEEKAED, corresponding to amino acids 309-326 of Rat Adenosine A1 Receptor. | | Localization: | Cell Membrane | Gene Symbol: ADORA1 | Entrez: | 134 (Human) | | | 29290 (Rat) | | Related Genes: | ADORA2A, RFC2, RFC1, ATP6V0A1, RFC4, ADA, ADORA3, CPA1, CA1, SGCA, C21orf2, GPHA2, ATP6V0A2, ADORA2B, TCFL5, ADCY7, A1AR, A1R, MAPK3, PKC, MAPK1, INS, EXOSC10, DHDDS, CHPT1, CA3, RPLP2, PMP2, PIK3CG, AKT1, A4GALT, ADK, AGT, RAPGEF5, MAPK12, B3GALNT1, PRM1, PRF1, RPLP1, TNF | Background: Adenosine receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily. Structural, biochemical and pharmacological analyses of the AR genes and protein has led to the discovery of four distinct AR subtypes (A1, A2a, A2b, A3). Activation of ARs mediates several receptor subtype-specific physiological processes that include cardiac rate, smooth muscle tone, platelet aggregation, inflammation, cell growth and death, and neurotransmission.The A1AR is a glycoprotein that can activate Gi and Go proteins in vitro. In intact cells, agonist occupation of the A1AR has been shown to cause pertussis toxin-sensitive inhibition of adenylyl cyclase activity and, in some systems, a stimulation of phospholipase C resulting in mobilization of intracellular calcium stores. Activation of potassium channels by A1AR has been intensively studied in relation to its dramatic effects on the cardiovascular system. A1AR protein is highly expressed in brain (especially cerebellum, hippocampus, thalamus, and cortex) and spinal cord and in part, modulates neurotransmitter release. In white adipocytes A1AR inhibits lipolysis and stimulates glucose uptake. Other tissues also express A1AR including kidney and testis. Species: | Reactivity: | Cross-reacts with Human, Rat and Cow.Not yet tested in other species. | Applications: | Uses: | Immunohistochemistry: use at a dilution of 1/100. Western Blot: use at a dilution of 1/1000. Not tested in other applications.Optimal dilutions / concentrations should be determined by the end user.By Western blot, this antibody detects an ~37 kDa protein in rat brain representing A1AR. Immunohistochemical staining of A1AR in human hippocampus yields a pattern consistent with plasma membrane staining. | | Dilutions: | Immunohistochemistry-Paraffin, immunoprecipitation, Western Blot, | | Concentrations: | 1.0 mg/ml | Packaging: | Buffer: | PBS, 1 mg/ml BSA and 0.05% sodium azide | | Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. | | Preservative: | 0.05% Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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