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Description |
Unit |
Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-310541 |
NLS7761 |
ADAMTS5 Antibody//Human/Rabbit |
1/EA |
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문의 |
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Subject
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ADAMTS5 Antibody |
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Description
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/ Human/Rabbit |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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IHC-P |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Hu | | Applications: | IHC-P | | Clonality: | Polyclonal | | | Gene: | ADAMTS5 | | Purity: | Immunogen affinity purified | | Host: | Rabbit | | | Specificity: | A Disintegrin-like and Metalloprotease with Thrombospondin Type 1 Motif, 5 (ADAMTS5) | Details: | Immunogen: | Metalloprotease domain of human | | Localization: | Secreted. Associated with the extracellular matrix. | Gene Symbol: ADAMTS5 | Entrez: | 11096 (Human) | | Related Genes: | ADAMTS4, ACAN, ADAMTS2, ADAMTS3, ADAMTS, MMP3, MMP13, ADAMTS1, MMP-13, TNF, IL1B, ADAMTS-1, MMP1, ADAM-TS5, VCAN, ADAM-TS4, ADAMTS9, TIMP-1, TIMP1, TIMP3, ADAM17, SLC25A12, IL6, NFKB1, RSPO3, MMP9, CD44, FGF2, IL18, FMOD, MAPK1, COL2A1, ADAMTS8, MMP16, NOS2, DCN, TGFB1, ADAMTS16, JUN, BMP2 | Background: ADAMTS5, also known as aggrecanase-2, is a Metallopeptidase M12B type protease that is responsible for degradation of the articular cartilage protein aggrecan. The protein contains a signal sequence, a prodomain with both a potential cysteine switch and a furin cleavage site, a metalloproteinase domain with a conserved zinc-binding motif and a 'met turn,' a disintegrin-like domain, and a spacer region between a thrombospondin type 1 motif and thrombospondin submotif. At least four transcript variants have been reported. ADAMTS5 has been implicated in inflammatory joint diseases. ADAMTS5 expression has been documented in a range of normal human tissues. ESTs have been isolated from human tissue libraries, including normal breast, embryo and heart and cancerous placenta and uterus. Species: | Reactivity: | Human. There is 44% identity and homology with mouse. There is 100% identity and homology with rat. | Applications: | Uses: | This antibody is useful for Immunohistochemistry-Paraffin. | | Dilutions: | Immunohistochemistry-Paraffin | | Concentrations: | 1.0 mg/ml | | Positive Controls: | 1 positive controls | Packaging: | Buffer: | Phosphate buffered saline, pH 7.7, | | Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. | | Preservative: | Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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