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Unit |
Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-310552 |
NB300-597 |
Adenosine A2a Receptor Antibody//Canine, Human/Rabbit |
1/EA |
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문의 |
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Subject
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Adenosine A2a Receptor Antibody |
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Description
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/ Canine, Human/Rabbit |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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IHC-P, IHC-P, IP, Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Rt, Hu, Ca | | Applications: | IHC-P, WB, IP, IHC | | Clonality: | Polyclonal | | | Gene: | ADORA2A | | Purity: | Affinity purified | | Host: | Rabbit | | | Specificity: | Detects adenosine receptor A2a. This does not detect other AR subtypes. | | Publications: | Antibody has not yet been mentioned in a publication. | Details: | Isotype: | IgG | | Immunogen: | Synthetic peptide: ESHGDMGLPDVELLSHELK, corresponding to amino acids 373-391 of Dog Adenosine Receptor A2a. | | Localization: | Cell Membrane | Gene Symbol: ADORA2A | Entrez: | 135 (Human) | | | 29290 (Rat) | | Related Genes: | ADORA1, RFC2, RFC1, ATP6V0A1, RFC4, ADORA3, ADORA2B, ADA, NF2, TNF, ADCY7, DIO2, PKA, MAPK1, MAPK3, CPA1, TNFRSF11A, FOS, MPO, VEGFA, ADO, BBS9, LMOD1, SGCA, C21orf2, CA1, GPHA2, ATP6V0A2, IL6, BDNF, GRM5, PKC, PIK3CG, A2AAR, GPR151, MRGPRX1, LGR6, OXER1, VN1R17P, LPAR3 | Background: Adenosine receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily. Structural, biochemical and pharmacological analyses of the AR genes and protein has led to the discovery of four distinct AR subtypes (A1, A2a, A2b, A3). Activation of ARs mediates several receptor subtype-specific physiological processes that include cardiac rate, smooth muscle tone, platelet aggregation, inflammation, cell growth and death, and neurotransmission. The A2aAR is a glycoprotein that can activate adenylyl cyclase via Gs interactions. Stimulation of A2aAR and the resultant accumulation of cAMP inhibits platelet aggregation and in certain vascular beds is associated with vasodilation and drop in blood pressure. A2aAR is reported to interact with D2 dopamine receptor sites in the brain where they co-express (striatum, olfactory tubercle and nucleus accumbens). Other tissues including heart, kidney, and lung also express A2aAR. Species: | Reactivity: | Cross-reacts with Human and Dog.Not yet tested in other species. | Applications: | Uses: | Immunohistochemistry (paraffin), Immunoprecipitation, Western Blot Not tested in other applications. Optimal dilution / concentration should be determined by the end user. By Western blot, this antibody detects an ~45 kDa protein from canine striatum representing A2aAR. Immunohistochemical staining of A2aAR in human hippocampus yields a pattern consistent with plasma membrane staining. | | Dilutions: | immunohistochemistry 1:100, immunoprecipitation Assay dependent, Western Blot 1:1,000, Immunohistochemistry-Paraffin 1:100 | | Concentrations: | 0.69 mg/ml | Packaging: | Buffer: | PBS, 1 mg/ml BSA | | Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. | | Preservative: | 0.05% Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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