|
|
Cat. No |
Model |
Description |
Unit |
Price (VATº°µµ) |
³³±â |
Àç°í |
DataSheet |
ÁÖ¹®/°ßÀû |
LCA-23-310630 |
NB600-504 |
Aggrecan Neoepitope Antibody (BC-3)//Bovine, Canine/Mouse |
1/EA |
|
|
|
|
¹®ÀÇ |
|
|
|
|
|
|
Subject
|
Aggrecan Neoepitope Antibody (BC-3) |
Description
|
/ Bovine, Canine/Mouse |
Clonality
|
Mono |
Company
|
Novus biologicals |
Application
|
ELISA, IHC-P, IHC-P, Western Blot |
Conjugation
|
|
Immunogen
|
|
Contents
|
Description:Summary: Species: | Sh, Fe, Eq, GP, Rb, Rt, Po, Mu(-), Hu, Ca, Bv | Applications: | IHC-Fr, IHC-P, WB, ELISA | Clonality: | Monoclonal | | Gene: | ACAN | Purity: | Tissue culture supernatant | Host: | Mouse | | Specificity: | Recognizes the aggrecanase (ADAMTS-1, -4 & -5)-generated N-terminal neoepitope ARG after cleavage between amino acids EGE and ARG within the interglobular domain of aggrecanase-catabolised aggrecan. | Publications: | Antibody has been mentioned in at least 1 publication. | Details: Clone: | BC-3 | Isotype: | IgG1 Kappa | Immunogen: | ARGSV... synthetic peptide conjugate. | Localization: | Secreted | Gene Symbol: ACAN Entrez: | 176 (Human) | | 11595 (Mouse) | | 58968 (Rat) | Related Genes: | VCAN, SLC25A12, DCN, ADAMTS4, MMP3, SOX9, BMP2, COMP, MMP13, MMP-13, COL2A1, ADAMTS5, ADAMTS2, BMP7, GALNS, ADAMTS3, TNF, BMP-2, CD44, IL1B, FMOD, NCAN, SPP1, OXSM, BGLAP, ADAMTS, BCAN, TIMP-1, MAPK1, MMP9, MMP1, CTGF, RUNX2, MSC, FGF2, TGFB1, PTPRZ1, IL6, MAPK3, INS | Background: Aggrecan degradation products containing this neoepitope are rapidly released from the tissue in model explant culture systems and are also present in the synovial fluids of patients with degenerative joint disease. Species: Reactivity: | Cross-reacts with Human, Cow, Cat, Dog, Guinea pig, Horse, Pig, Rabbit, Rat and Sheep. Does not react with Mouse. Not yet tested in other species. | Applications: Uses: | This antibody should work in IHC on formalin- or paraformaldehyde-fixed paraffin embedded sections as well as either alcohol-fixed frozen sections or un-fixed snap-frozen sections. This antibody can also be used with ELISA and Western blot, where it detects a variety of epitopes between 50 and 250 kDa. | Dilutions: | ELISA Use at an assay dependent dilution, Western Blot 1/100, Immunohistochemistry-Paraffin Use at an assay dependent dilution, Immunohistochemistry-Frozen Use at an assay dependent dilution | Packaging: Buffer: | 0.2M Tris/HCl pH 7.4, 01-10% foetal calf serum | Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. | Preservative: | 0.02% Sodium Azide | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
|
|
|
|