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| Cat. No |
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Description |
Unit |
Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-310696 |
NB110-57279 |
AKT1 Antibody (E45)//Human, Mouse,/Rabbit |
1/EA |
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문의 |
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Subject
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AKT1 Antibody (E45) |
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Description
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/ Human, Mouse,/Rabbit |
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Clonality
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Mono |
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Company
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Novus biologicals |
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Application
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ICC, IHC-P, IP |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Rt, Mu, Hu | | Applications: | ICC, IHC, IP | | Clonality: | Monoclonal | | | Gene: | AKT1 | | Purity: | IgG purified | | Host: | Rabbit | | | Specificity: | A synthetic peptide corresponding to residues surrounding Ser473 of human Akt1 was used as immunogen. The can detects Akt1 and Akt3. Predicted to cross-react with bovine based on sequence homology | | Publications: | Antibody has not yet been mentioned in a publication. | Details: Gene Symbol: AKT1 | Entrez: | 207 (Human) | | | 11651 (Mouse) | | | 24185 (Rat) | | Swiss Prot: | P31749 (Human) | | Related Genes: | PIK3CG, PTK2B, MAPK1, PIK3CA, PIK3CB, PIK3CD, MAPK3, EPHB2, INS, MTOR, EGFR, PTEN, CASP3, VEGFA, INSR, MAPK8, EGF, MAPK12, NFKB1, MAPK14, GRAP2, AHSA1, AIMP2, SLC2A4, CDC42, SRC, BCL2L1, BCL2, NOS3, RHO, RHOD, CDKN1A, IRS1, TNF, ERBB2, PSMC4, JUN, PTK2, FOXO1, IRS-1 | Background: Akt1/PKBalpha is a Ser/Thr protein kinase whose kinase activity plays a key role in various cellular functions, including apoptosis, glycogen synthesis, and cell growth . Akt1/PKBalpha is activated by various growth and survival factors (1). Phosphorylation on Thr308, Ser473 and Tyr474 is required for full activity. Akt1/PKBalpha inhibits apoptosis by phosphorylating and inactivating several targets, including caspase-9 (2). Akt1/PKBalpha regulates glycogen synthesis by phosphorylating and inactivating glycogen synthase kinase-3a and b (3,4). Three mammalian Akt1/PKBalpha isoforms have been identified. Species: | Reactivity: | Cross reacts in Human, Mouse and Rat. | Applications: | Uses: | Immunohistochemistry, Immunoprecipitation and Immunocytochemistry | | Dilutions: | immunohistochemistry 1:1000?2500, immunoprecipitation 1:100, Immunocytochemistry 1:1000 | Packaging: | Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. | | Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. | | Preservative: | 0.01% Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | | | | |
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