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| Cat. No |
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Description |
Unit |
Price
(VAT별도) |
납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-310702 |
NB600-590 |
AKT1 [phospho Ser473] Antibody//Human/Rabbit |
1/EA |
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문의 |
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Subject
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AKT1 [phospho Ser473] Antibody |
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Description
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/ Human/Rabbit |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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ELISA, ICC, IF, IHC-P, Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Hu | | Applications: | IHC-P, ICC, WB, IF, ELISA | | Clonality: | Polyclonal | | | Gene: | AKT1 | | Purity: | Whole antisera | | Host: | Rabbit | | | Specificity: | AKT [Ser473] | Details: | Modification: | phospho Ser473 | | Isotype: | IgG | | Immunogen: | Synthetic peptide: CHFPQFSpYSAS conjugated to KLH, corresponding to amino acids 468-477 of Human AKT. | | Localization: | Cytoplasmic and Nuclear | Gene Symbol: AKT1 | Entrez: | 207 (Human) | | Related Genes: | PIK3CG, PTK2B, MAPK1, PIK3CA, PIK3CB, PIK3CD, MAPK3, EPHB2, INS, MTOR, EGFR, PTEN, CASP3, VEGFA, INSR, MAPK8, EGF, MAPK12, NFKB1, MAPK14, GRAP2, AHSA1, AIMP2, SLC2A4, CDC42, SRC, BCL2L1, BCL2, NOS3, RHO, RHOD, CDKN1A, IRS1, TNF, ERBB2, PSMC4, JUN, PTK2, FOXO1, IRS-1 | Background: The serine threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet derived growth factor. The activation is rapid and specific. In the developing nervous system AKT is a critical mediator of growth factor induced neuronal survival. Survival factors can suppress apoptosis in a transcription independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene (referenced from entrez gene). Species: | Reactivity: | Cross-reacts with Human. Not yet tested in other species. | Applications: | Uses: | This antibody is useful for ELISA, Western blot, immunofluorescence/immunocytochemistry, immunohistochemister-Paraffin. For immunohistochemistry, no pre-treatment of sample is required. | | Dilutions: | ELISA 1:15000 - 1:60000, immunofluorescence , Western Blot 1:200-1:1000, Immunocytochemistry , Immunohistochemistry-Paraffin 1:100-1:500 | Packaging: | Buffer: | 0.02M K Phosphate, 0.15M NaCl, pH7.2 | | Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. | | Preservative: | 0.01% Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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