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Description |
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Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-310827 |
NB300-277 |
5 Lipoxygenase [phospho Ser523] Antibody//Human, Rat/Rabbit |
1/EA |
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문의 |
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Subject
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5 Lipoxygenase [phospho Ser523] Antibody |
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Description
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/ Human, Rat/Rabbit |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Rt, Hu | | Applications: | WB | | Clonality: | Polyclonal | | | Gene: | ALOX5 | | Purity: | Immunogen affinity purified | | Host: | Rabbit | | | Specificity: | Specific for the ~80k 5-LO phosphorylated at Ser523 in Western blots of rat hippocampal lysate. | | Publications: | Antibody has not yet been mentioned in a publication. | Details: | Modification: | phospho Ser523 | | Immunogen: | Phosphopeptide corresponding to amino acids residues surrounding the phospho Ser523 of human 5-Lipoxgenase (5-LO). | | Localization: | Cytoplasmic | Gene Symbol: ALOX5 | Entrez: | 240 (Human) | | | 25290 (Rat) | | Related Genes: | CD19, PTGS2, ALOX5AP, ALOX12, C4A, ALOX15, LTB, LTA4H, LOX, YWHAZ, TNF, APP, PTGS1, SGCG, ATP6V0A4, PLP2, COX8A, COX5A, GSTP1, MPO, PLEKHM1, MAPK1, PLA2G6, ARHGDIB, LTB4R, PLA2G2A, CYSLTR1, CYSLTR2, PLA2G4A, PLA2G1B, 5LO, LTA, 12-LO, KIAA0101, KAT5, MAPK3, PTGDS, UBE4B, IL4, UBE4A | Background: The enzyme 5-lipoxygenase (5-LO) play a key role in regulating the production of leukotrienes (LTs) (Funk, 2001). Overproduction of LTs contribute to several diseases, most notably chronic inflammatory diseases, including asthma (Drazen et al., 1994) fibrosis (Wilborn et al., 1996) and atherosclerosis (Dwyer et al., 2004). Recent work has demonstrated that the activity of 5-LO is regulated by PKA phosphorylation of serine523 in 5-LO (Luo et al., 2004). Under normal conditions, this phosphorylation may be important in limiting inflammation. Abnormal signaling through cAMP and PKA could contribute to a variety of diseases, including those characterized by chronic inflammation. The phospho-specific antibody to ser523 on 5-LO is thus likely to provide a valuable tool for studies of the role of 5-LO regulation in diseases such as asthma, fibrosis, and atherosclerosis. Species: | Reactivity: | Recognizes human and rat forms of 5-LO. | Applications: | Uses: | Western Blot | | Dilutions: | Western Blot 1:1000 | Packaging: | Buffer: | 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% glycerol | | Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. | | Preservative: | No Preservative | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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