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Cat. No |
Model |
Description |
Unit |
Price (VATº°µµ) |
³³±â |
Àç°í |
DataSheet |
ÁÖ¹®/°ßÀû |
LCA-23-310933 |
S-024-100 |
alpha Synuclein Antibody//Human, Mouse,/Sheep |
1/EA |
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Subject
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alpha Synuclein Antibody |
Description
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/ Human, Mouse,/Sheep |
Clonality
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Poly |
Company
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Novus biologicals |
Application
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IHC-P |
Conjugation
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Immunogen
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Contents
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Description:Summary: Protein Type: | Peptide | Species: | Rt, Mu, Hu | Applications: | IHC | Clonality: | Polyclonal | | Gene: | SNCA | Purity: | Whole antisera | Host: | Sheep | | Specificity: | Immunohistochemistry shows a high specificity for alpha-synuclein. | Publications: | Antibody has been mentioned in at least 10 publications. | Details: Immunogen: | A synthetic peptide (CMPVDPDNEAYEMPSEE) as part of human alpha synuclein (aa: 116-113) | Localization: | Accession Number: SYUA_HUMAN | Gene Symbol: SNCA Entrez: | 6622 (Human) | | 20617 (Mouse) | | 29219 (Rat) | Related Genes: | PARK2, MAPT, SNCB, PARK7, SNCAIP, TH, APP, LRRK2, UCHL1, PINK1, PRNP, NLRP1, UCHL3, HTT, TPO, SYP, CASP3, SLC6A3, HSPA4, SCG2, SIGLEC1, PSEN1, SOD1, YWHAQ, APOE, MAPK1, TPPP, TG, CYCS, FAM49B, TNF, CHM, MAPK8, MPZ, MPHOSPH6, ATP13A2, BDNF, AKT1, NR4A2, SNCG | Background: Alpha synuclein is an abundant 140 amino acid neuronal protein, expressed primarily at presynaptic terminals in the central nervous system. Alpha synuclein has been associated with several neurodegenerative diseases. A point mutation in the gene coding for the alpha-synuclein protein was the first discovery linking this protein to a rare familial form of Parkinson's disease (PD). Subsequently, other mutations in the alpha-synuclein gene have been identified in familial PD. The aggregated proteinaceous inclusions called Lewy bodies found in PD and cortical Lewy body dementia (LBD) were discovered to be predominantly alpha-synuclein. Aberrant aggregation of alpha-synuclein has been detected in an increasing number of neurodegenerative diseases, collectively known as synucleopathies. Alpha-synuclein exists physiologically in both soluble and membrane-bound states, in unstructured and alpha-helical conformations, respectively. The physiological function of alpha-synuclein appears to require its translocation between these subcellular compartments and interconversion between the 2 conformations. Abnormal processing of alpha-synuclein is predicted to lead to pathological changes in its binding properties and function (1). Species: Reactivity: | Reacts with human, rat and mouse alpha-synuclein. | Applications: Uses: | Immunohistochemistry | Dilutions: | immunohistochemistry 1:1000 to 1:2000 | Positive Controls: | 1 positive controls | Packaging: Buffer: | Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material. | Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. | Preservative: | No Preservative | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | | | |
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