|
| |
| Cat. No |
Model |
Description |
Unit |
Price
(VAT별도) |
납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-311058 |
NB600-1434 |
Actin Alpha 2 Smooth Muscle Antibody//Bovine, Chicken/Rabbit |
1/EA |
|
|
|
|
문의 |
|
|
|
|
|
|
|
Subject
|
Actin Alpha 2 Smooth Muscle Antibody |
|
Description
|
/ Bovine, Chicken/Rabbit |
|
Clonality
|
Poly |
|
Company
|
Novus biologicals |
|
Application
|
IHC-P |
|
Conjugation
|
|
|
Immunogen
|
|
|
Contents
|
Description:Summary: | Species: | Rb, Rt, Mk, Mu, Hu, Ch, Bv | | Applications: | IHC-P | | Clonality: | Polyclonal | | | Gene: | ACTA2 | | Purity: | Immunogen affinity purified | | Host: | Rabbit | | | Specificity: | Smooth Muscle Actin | Details: | Isotype: | IgG | | Immunogen: | Synthetic peptide (unfortunately, the amino acid sequence is considered to be commercially sensitive) (Human) (N terminal). | | Localization: | Cytoplasmic | Gene Symbol: ACTA2 | | 11475 (Mouse) | | | 81633 (Rat) | | Related Genes: | MYH7, DES, ACTC1, NPPA, MYOD1, MYOG, MYH14, MYL1, NKX2-5, ACTA1, PLN, TTN, TGFBR1, GJA1, CDKN1A, TNNT2, HNRNPC, C2, PCNA, LMNA, MLC1, TGFBR2, HESX1, ELSPBP1, SGCD, HAND1, MSTN, GATA4, VCL, PSMD1, MYC, MYF5, MYF6, NOL3, VCAN, MYH11, FBN1, TGFB1, MSC, TNFRSF11A | Background: MiTF (Microphthalmia associated transcription factor) is a basic helix loop helix leucine zipper (b HLH ZIP) transcription factor implicated in pigmentation, mast cells and bone development. Mutations in MiTF cause auditory pigmentary syndromes, such as Waardenburg syndrome type II, type IIa and Tietz syndrome in humans. There are two known isoforms of MiTF differing by 66 amino acids at the NH2 terminus. Shorter forms are expressed in melanocytes and run as two bands at 52kDa and 56kDa, while the longer Mi form runs as a cluster of bands at 60-70kDa in osteoclasts and in B16 melonoma cells (but not other melanoma cell lines), as well as mast cells and heart. MiTF plays a critical role in the differentiation of various cell types as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium. Species: | Reactivity: | Cross-reacts with Rabbit, Human, Mouse, Rat, Cow, Baboon and Chicken.Not yet tested in other species. | Applications: | Uses: | IHC-P: Ready to use for 10 min at RT. No special pretreatment is required for the immunohistochemical staining of formalin/paraffin tissues. Optimal dilutions/concentrations should be determined by the end user. | | Dilutions: | Immunohistochemistry-Paraffin | Packaging: | Buffer: | PBS, BSA | | Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. | | Preservative: | Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
|
|
|
|
