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Description |
Unit |
Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-311059 |
NB600-531 |
Actin Alpha 2 Smooth Muscle Antibody//Ba, Bovine,/Rabbit |
1/EA |
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문의 |
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Subject
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Actin Alpha 2 Smooth Muscle Antibody |
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Description
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/ Ba, Bovine,/Rabbit |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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ELISA, IHC-P, Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Rb, Rt, Po, Hu, Ch, Bv, Ba | | Applications: | IHC-P, WB, ELISA | | Clonality: | Polyclonal | | | Gene: | ACTA2 | | Purity: | Immunogen affinity purified | | Host: | Rabbit | | | Specificity: | This stains smooth muscle cells in vessel walls, gut wall, and myometrium. Myoepithelial cells in breast and salivary gland are also stained. It reacts with tumors arising from smooth muscles and myoepithelial cells. | | Publications: | Antibody has been mentioned in at least 2 publications. | Details: | Isotype: | IgG | | Immunogen: | Synthetic peptide corresponding to N-terminus of human alpha smooth muscle isoform of actin. | | Localization: | Cytoplasmic | Gene Symbol: ACTA2 | Entrez: | 59 (Human) | | | 25365 (Rat) | | Related Genes: | MYH7, DES, ACTC1, NPPA, MYOD1, MYOG, MYH14, MYL1, NKX2-5, ACTA1, PLN, TTN, TGFBR1, GJA1, CDKN1A, TNNT2, HNRNPC, C2, PCNA, LMNA, MLC1, TGFBR2, HESX1, ELSPBP1, SGCD, HAND1, MSTN, GATA4, VCL, PSMD1, MYC, MYF5, MYF6, NOL3, VCAN, MYH11, FBN1, TGFB1, MSC, TNFRSF11A | Background: Actins are highly conserved proteins expressed in all eukaryotic cells. Actin filaments form part of the cytoskeleton and play essential roles in regulating cell shape and movement. Six distinct actin isotypes have been identified in mammalian cells. Each is encoded by a separated gene and is expressed in a developmentally regulated and tissue-specific manner, alpha and beta cytoplasmic actins are expressed in a wide variety of cells; whereas, expression of alpha skeletal, alpha cardiac, alpha vascular, and gamma enteric actins are more restricted to specialized muscle cell type. Smooth muscle alpha actin is of further interest because it is one of a few genes whose expression is relatively restricted to vascular smooth muscle cells. Further more, expression of smooth muscle alpha actin is regulated by hormones, cell proliferation , and altered by pathological conditions including oncogenic transformation and atherosclerosis. Species: | Reactivity: | Cross-reacts with Baboon, Chicken, Cow, Human, Mouse, Rabbit, Pig and Rat. | Applications: | Uses: | This antibody can be used in ELISA, Western blot and Immunohistochemistry with formalin fixed paraffin embedded sections. In Western Blot there is a predicted band at 42 kDa. | | Dilutions: | ELISA 0.1 - 1.0 ug/ml, Western Blot 0.5 - 2.0 ug/ml, Immunohistochemistry-Paraffin 1:100-1:400 | | Concentrations: | 0.2 mg/ml | | Positive Controls: | 1 positive controls | Packaging: | Buffer: | PBS [pH 7.4] | | Storage: | Store at 4C. Do not freeze. | | Preservative: | 0.09% Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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