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| Cat. No |
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Description |
Unit |
Price
(VAT별도) |
납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-311107 |
NB600-898 |
Apc1 Antibody//Bovine, Canine/Rabbit |
1/EA |
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문의 |
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Subject
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Apc1 Antibody |
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Description
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/ Bovine, Canine/Rabbit |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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ELISA, Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Mu, Ca, Bv, Rt, Hu | | Applications: | WB, ELISA | | Clonality: | Polyclonal | | | Gene: | ANAPC1 | | Purity: | Immunogen affinity purified | | Host: | Rabbit | | | Specificity: | Less than 1% reactivity is observed against the non-phosphorylated form of the immunizing peptide. This is expected to be phospho-specific for S355 of APC1. | | Publications: | Antibody has not yet been mentioned in a publication. | Details: | Isotype: | IgG | | Immunogen: | Synthetic peptide: SRAHSpPALG conjugated to KLH, corresponding to amino acids 351-359 of Human Apc1. | Gene Symbol: ANAPC1 | Entrez: | 64682 (Human) | | | 17222 (Mouse) | | | 311412 (Rat) | | Related Genes: | APC, PROC, ANAPC2, APOC2, SLC25A23, APC2, CDC27, CDC16, CDC23, RNF123, ANAPC10, CDC20, WNT1, CDH1, PCSK1, PLK1, CTNNB1, FZR1, ANKS1B, MAPRE2, ANAPC11, CDK2AP1, BUB1, ESR1, MAPRE1, COX7A2L, PARK2, SCARA3, ANAPC7, MUL1, SLC25A25, TPR, TRIM50, PKA, MAD2L1, MTPN, CCNA2, CCND2, C10orf46, ANAPC4 | Background: APC1 is 1 of at least 11 subunits of the anaphase promoting complex (APC), which functions at the metaphase to anaphase transition of the cell cycle and is regulated by spindle checkpoint proteins. The APC is an E3 ubiquitin ligase that targets cell cycle regulatory proteins for degradation by the proteasome, thereby allowing progression through the cell cycle. This is one of a number of novel phosphorylation sites for APC1 identified in Kraft C et al. It may be involved in the regulation of the APC/C. Species: | Reactivity: | Reacts with Human, rat, bovine, canine and mouse. | Applications: | Uses: | Western blot and ELISA Product has been tested against 0.1 ug of the phosphorylated and non-phosphorylated forms of the immunizing peptide. In Western Blot detects a band of approximately 215 kDa (predicted molecular weight 215 kDa). | | Dilutions: | ELISA 1:10000 - 1:40000, Western Blot 1:200 - 1:2000 | | Concentrations: | 0.55 mg/ml | Packaging: | Buffer: | 0.15M Sodium Chloride, 0.02M Potassium Phosphate | | Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. | | Preservative: | 0.01% Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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