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Description |
Unit |
Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-312172 |
NB110-55656 |
Active Caspase 2 Antibody (Y154)//Human, Mouse(-)/Rabbit |
1/EA |
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문의 |
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Subject
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Active Caspase 2 Antibody (Y154) |
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Description
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/ Human, Mouse(-)/Rabbit |
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Clonality
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Mono |
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Company
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Novus biologicals |
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Application
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IP, Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Rt(-), Mu(-), Hu | | Applications: | WB, IP | | Clonality: | Monoclonal | | | Gene: | CASP2 | | Purity: | IgG purified | | Host: | Rabbit | | | Specificity: | A synthetic peptide corresponding to C-terminus of human Caspase-2 p18 subunit was used as immunogen. The should recognize both pro-form (~50kDa) and p18 cleaved-form of Caspase-2. Predicted to detect the splice isoform (35 kDa) based on sequence homology | | Publications: | Antibody has not yet been mentioned in a publication. | Details: | Clone: | Y154 | | Isotype: | IgG | | Immunogen: | Synthetic peptide corresponding to residues in the C terminus of Human Caspase 2 p18 subunit. | Gene Symbol: CASP2 | Entrez: | 835 (Human) | | | 12366 (Mouse) | | | 64314 (Rat) | | Swiss Prot: | P42575 (Human) | | Related Genes: | CASP3, CASP9, CASP8, CASP1, CYCS, BCL2L1, BCL2, CASP7, BAX, PARP1, BID, CASP6, CRADD, FAS, TP53, ICH-1, LRDD, COL11A2, APAF1, FASLG, DIABLO, BAK1, FADD, TNFSF10, AIFM1, MAPK8, TNF, CDKN1A, CUX1, CASP10, MCL1, CRTAP, CYTIP, NFKB1, GZMB, RIPK1, AKT1, XIAP, JUN, HTT | Background: Caspase-2 (Nedd2/ICH-1) is part of a family of aspartate-specific cysteine proteases that participate in programmed cell death, or apoptosis. Caspase-2 is localized to the nucleus, and has been shown to play roles in both positive and negative regulation of apoptosis (1). Upon apoptotic stimulation, pro-caspase-9 is cleaved in a series of steps to produce an 18-kDa large subunit and a 12-kDa small fragment (2). Caspase-2 can be a nuclear initiator caspase, as it has been shown to precede the processing and activation of caspase-8, -9, and -3 (3). Caspase-2 might also act as an effector caspase; in apoptotic pathways resulting from UV-induced DNA damage, processing of caspase-2 occurs downstream of caspase-9 and caspase-3 activation (4). Species: | Reactivity: | Reacts in Human. does not react in Mouse or Rat. Not tested in other species. | Applications: | Uses: | This antibody is useful for immunoprecipitation and Western Blot. | | Dilutions: | immunoprecipitation 1:20, Western Blot 1:500 | Packaging: | Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. | | Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. | | Preservative: | 0.01% Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | | | | |
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