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Description |
Unit |
Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-312173 |
NB120-7979 |
Active Caspase 2 Antibody//Human, Mouse,/Rabbit |
1/EA |
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문의 |
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Subject
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Active Caspase 2 Antibody |
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Description
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/ Human, Mouse,/Rabbit |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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IHC-P, IP, Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Rt, Mu, Hu | | Applications: | WB, IP, IHC | | Clonality: | Polyclonal | | | Gene: | CASP2 | | Purity: | IgG purified | | Host: | Rabbit | | | Specificity: | Reacts with caspase-2L p12 subunit. | | Publications: | Antibody has been mentioned in at least 1 publication. | Details: | Isotype: | IgG | | Immunogen: | Synthetic peptide correspdoning to the C-terminal of human caspase 2L | Gene Symbol: CASP2 | Entrez: | 835 (Human) | | | 12366 (Mouse) | | | 64314 (Rat) | | Related Genes: | CASP3, CASP9, CASP8, CASP1, CYCS, BCL2L1, BCL2, CASP7, BAX, PARP1, BID, CASP6, CRADD, FAS, TP53, ICH-1, LRDD, COL11A2, APAF1, FASLG, DIABLO, BAK1, FADD, TNFSF10, AIFM1, MAPK8, TNF, CDKN1A, CUX1, CASP10, MCL1, CRTAP, CYTIP, NFKB1, GZMB, RIPK1, AKT1, XIAP, JUN, HTT | Background: Caspases is a family of mammalian proteases that regulate many of the morphological and biochemical features of apoptosis. The currently identified caspases can be divided into three groups: apoptotic initiators, apoptotic executioners, and inflammatory mediators (1,2). Caspase-2, 8, and 9 have been identified as apoptotic initiators (3,4). Caspase-2 (also designated Nedd-2/ICH-1) can be alternatively spliced to produce two distinct Caspase-2 mRNA species. One mRNA species encodes a protein of 435 amino acids in length and the mRNA splice variant encodes a 312 amino acid protein. The larger protein, Caspase-2L, in an over expressed state, leads to programmed cell death. Conversely the over expression of Caspase-2S protein, a truncated version of Caspase-2L, has been shown to suppress cell death induced by serum deprivation (5). The executioner caspases include caspase-3, 6 and 7. Of these three proteases Caspase-3 is considered to be the essential for the chromatin margination, DNA fragmentation, and nuclear collapse during apoptosis (6). Caspase-1 (also known as ICE) is considered to be a mediator of the inflammatory response by converting the inactive precursor of interleukin-1â to the 17 kDa proinflammatory cytokine, IL-1â (7,8). Species: | Reactivity: | Cross-reacts with Human, Rat and Mouse. Not yet tested in other species. | Applications: | Uses: | This antibody is useful for Immunohistochemistry, Immunoprecipitation and Western Blot. | | Dilutions: | immunohistochemistry Use at an assay dependent dilution, immunoprecipitation Use at an assay dependent dilution, Western Blot 1/200 | | Concentrations: | 0.2 mg/ml | | Positive Controls: | 2 positive controls | Packaging: | Buffer: | PBS, 0.2% gelatin | | Storage: | Store at 4C. Do not freeze. | | Preservative: | 0.1% Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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