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Description |
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Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-313885 |
NB120-22585 |
E Cadherin Antibody (SPM471)//Human/Mouse |
1/EA |
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문의 |
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Subject
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E Cadherin Antibody (SPM471) |
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Description
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/ Human/Mouse |
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Clonality
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Mono |
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Company
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Novus biologicals |
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Application
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IHC-P |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Hu | | Applications: | IHC-P | | Clonality: | Monoclonal | | | Gene: | CDH1 | | Purity: | protein A purified | | Host: | Mouse | | | Specificity: | E Cadherin (SPM471) | Details: | Clone: | SPM471 | | Isotype: | IgG2b Kappa | | Immunogen: | Recombinant fragment: IFFCERNPKP QVINIIDADL PPNTSPFTAE LTHGASANWT IQYNDPTQES IILKPKMALE VGDYKINLKL MDNQNKDQVT TLEVSVCDCE GAAGVCRKAQ PVEAGLQI, corresponding to C terminal amino acids 600-707 of Human E Cadherin. | | Epitope: | amino acids 600-707 | | Localization: | Cell membrane; cell-cell junction; single-pass type I membrane protein. | Gene Symbol: CDH1 | Entrez: | 999 (Human) | | | 4757960 (Api) | | Related Genes: | CTNNB1, CTNNA1, APC, CDKN2A, PROC, TP53, SLC22A3, ITK, EGFR, VIM, JUP, FZR1, HGF, TJP1, ERBB2, CD44, VEGFA, MMP9, AKT1, RASSF1, MLH1, CCND1, EGF, CDKN1A, OCLN, CTNND1, PIK3CG, GSTP1, MGMT, PCNA, MYC, BCL2, SUB1, SNAI2, CDKN2B, IL6, CDC20, SRC, MMP-2, MMP2 | Background: One of the epithelial cell adhesion molecules, E Cadherin, plays an important role in the formation of cell-cell contacts in epithelia irrespective their origin form ecto-, meso- or endodermal tissue. This early adhesion event between epithelial cells is a prerequisite for the assembly of all elements of the junctional complex. Furthermore, E Cadherin plays a crucial role in the maintenance of the epithelial junctional complex and is as such an important molecule in maintaining epithelial integrity. Over 90% of the malignant tumors are carcimomas. One of the prerequisites for the release of carcinoma cells from the primary site might be a defect in intercellular adhesion mediated by the absence of E Cadherin expression. Therefore, the expression of E Cadherin might be an important parameter for the determination of the invasive potential of epithelial neoplasms, and for the transition of a benign to a malignant neoplasm. Species: | Reactivity: | Cross-reacts with Human.Expected to cross-react with Orangutan (95%) due to sequence homology.Not yet tested in other species. | Applications: | Uses: | IHC-P: 1/100 for 30 min at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. | | Dilutions: | Immunohistochemistry-Paraffin | | Concentrations: | 0.2 mg/ml | Packaging: | Buffer: | BSA, 10mM PBS. pH 7.4 | | Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. | | Preservative: | Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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