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Unit |
Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-313918 |
NB100-2177 |
ABCG2 Antibody (BXP-21) - Hematopoietic Stem Cell Marker//Human/Mouse |
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Subject
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ABCG2 Antibody (BXP-21) - Hematopoietic Stem Cell Marker |
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Description
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/ Human/Mouse |
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Clonality
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Mono |
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Company
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Novus biologicals |
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Application
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ICC, IHC-P, IHC-P, Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Hu | | Applications: | IHC-Fr, IHC-P, ICC, WB | | Clonality: | Monoclonal | | | Gene: | ABCG2 | | Purity: | Tissue culture supernatant | | Host: | Mouse | | | Specificity: | This recognizes an internal epitope of human BCRP (70 kDa), a transmembrane half-transporter. The does not cross-react with the human MDR1, MRP1, and MRP2 gene products. | | Publications: | Antibody has been mentioned in at least 1 publication. | Details: | Clone: | BXP-21 | | Isotype: | IgG2a | | Immunogen: | Fusion protein composed of E. Coli maltose binding protein and BCRP peptide [126 amino acids, 271-396 AA of BCRP. | | Marker: | Hematopoietic Stem Cell Marker | | Localization: | Plasma membrane; integral membrane protein | Gene Symbol: ABCG2 | Entrez: | 9429 (Human) | | Related Genes: | ABCB1, ABCC1, ABCC2, MSH3, MDM4, TBC1D9, KLHL1, MARCKSL1, GPR177, MVP, BANF1, PGPEP1, ABCC3, ABCC4, EGFR, ABCC5, LRP1, PTPRA, RPSA, SLCO1B1, ABCB4, MTX1, ABCB11, CD34, CD9, CYP3A4, SLCO1A2, CKAP4, NR1I2, TP63, SLCO1B3, SLCO2B1, NES, GSTP1, UVRAG, RPE65, SLC22A1, TOP1, CFTR, KRT3 | Background: Tumor cells may display a multidrug resistant phenotype by overexpression of ATP-binding cassette transporters such as multidrug resistance (MDRI) p-glycoprotein, multidrug resistance protein 1 (MRP1), and breast cancer resistance protein (BCRP). Tumor cells can be intrinsically resistant to drugs or they can acquire resistance to structurally and functionally unrelated drugs on drug exposure. This phenomenon is known as multidrug resistance (MDR). In human tumor cells, several transporter proteins can be involved in MDR. These proteins, MDR1 P-gp (ABCB1), MRP1 (ABCC1), MRP2 (ABCC2), MRP3 (ABCC3), and BCRP (ABCG2), belong to the ABC transporter family. They act as efflux pumps, which result in decreased intracellular concentrations of cytotoxic drugs. BCRP is a recently discovered half-transporter that probably acts as a homo- or heterodimer in transporting cytotoxic agents. The transporter molecule is capable of transporting several anticancer drugs but has thus far been found mainly in MX-resistant cell lines. Species: | Reactivity: | Cross-reacts with Human. Not yet tested in other species. | Applications: | Uses: | ICC: Using immunocytochemistry on acetone-fixed, frozen cytospin preparations. IHC: Using immunohistochemistry on acetone-fixed, frozen sections using rabbit anti-mouse IgG and a APAAP complex. The antibody can be used on formalin-fixed, paraffinembedded human tissues and tumors after pretreatment with 10 mM citric acid, pH 6.0, for 20 minutes. WB: Use at assay dependant dilution. | | Dilutions: | Western Blot , Immunocytochemistry 1/20 to 1/50 , Immunohistochemistry-Paraffin 1/20-1/40, Immunohistochemistry-Frozen 1/20-1/40, | | Concentrations: | 0.25 mg/ml | | Positive Controls: | 1 positive controls | Packaging: | Buffer: | PBS with 0.7% BSA | | Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. | | Preservative: | Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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