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Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-314193 |
NBP1-05048SS |
RAB7A//Human, Mouse, Rat, Bovine, Canine, Sheep/Rabbit |
1/EA |
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문의 |
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Subject
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RAB7A |
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Description
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/ Human, Mouse, Rat, Bovine, Canine, Sheep/Rabbit |
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Clonality
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Mono |
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Company
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Novus biologicals |
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Application
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Western blot / Immunoblot |
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Conjugation
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Immunogen
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Contents
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Description: | Manufacturer | Novus Biologicals Inc. | | Quantity | 0.025 ml | | Reactivity | Human, Mouse, Rat, Bovine, Canine, Sheep | | Presentation | Serum | | Applications | Western blot / Immunoblot | | Host | Rabbit | | PDF datasheet | view | | Shipping to | Not USA/Canada | | Synonyms | RAB7A, RAB7, Ras-related protein Rab-7a | | Swiss Prot Num | P51149 | | Immunogen | Recombinant full length human RAB7 protein [Swiss-Prot# P51149] | | Product Type | Antibodies | | Storage | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. | | References | 1. Cantalupo G. et. al. Rab-interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes. EMBO J. 20:683-693(2001) 2. Verhoeven K. et. al. Mutations in the small GTP-ase late endosomal protein RAB7 cause Charcot-Marie-Tooth type 2B neuropathy. Am. J. Hum. Genet. 72:722-727(2003) 3. Wu, M. et. al. Structural basis for recruitment of RILP by small GTPase Rab7. EMBO J. 24:1491-1501(2005) 4. Meggouh F. et al. Charcot-Marie-Tooth disease due to a de novo mutation of the RAB7 gene. Neurology 67:1476-1478(2006) | |
| Format | Purity: Whole antisera | | ? | Purification: Whole antisera | | ? | Buffer System: 0.1% Sodium Azide | |
| Specificity | , RAB7 | | Add. information | Research Areas: Cellular Markers | | Application | Western Blot, This antibody is useful for Western blot, where a band is seen ~23 kDa., Western Blot 1:1000, | | Background | RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. RAB7 is a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. | |
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