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Description |
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Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-315169 |
NB100-1423 |
ACTR1A Antibody//Human/Goat |
1/EA |
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문의 |
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Subject
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ACTR1A Antibody |
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Description
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/ Human/Goat |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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PEP-ELISA, Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Hu | | Applications: | WB, PEP-ELISA | | Clonality: | Polyclonal | | | Gene: | ACTR1A | | Purity: | Immunogen affinity purified | | Host: | Goat | | | Specificity: | This may crossreact with ACTR1B | | Publications: | Antibody has not yet been mentioned in a publication. | Details: | Isotype: | IgG | | Immunogen: | Synthetic peptide: YEEDGARSIHRKT representing the C-terminus of the human protein (residues 363-375) according to NP_005727. | | Localization: | Cytoplasmic | Gene Symbol: ACTR1A | Entrez: | 10121 (Human) | | | 54130 (Mouse) | | Swiss Prot: | NP_005727. (Human) | | Related Genes: | ACTL6B, NR2F1, NR2F2, CHAF1A, ABL1, ANPEP, CTR9, PIK3R4, ARFRP1, ACTR2, ANGPTL2, ACTR3B, AICDA, MANF, CRISP1, RERE, DCTN2, NUP62, IGF2BP2, KHDRBS1, SQSTM1, ANGPTL4, ACTL6A, APOBEC3B, TPPP, DBNL, PITX2, ACTR3, CD9, NR2F6, APOBEC3A, ANGPTL1, ACTR10, ANGPTL6, HNF4A, NRSN1, KIF2C, NUMA1, APOBEC3D, APOBEC2 | Background: The actin-related protein ACTR1A, a member of the superfamily of actin-related proteins, is the major subunit of the dynactin complex, a key component of the cytoplasmic dynein motor machinery. The major components of the dynactin complex, consisting of at least ten polypeptides, include ACTR1A. ACTR1A, the most abundant subunit in the dynactin complex, is most similar to conventional actin (>50% amino acid identity). The dynactin complex has been shown to localize to multiple structures within the cell, including membrane organelles, the centrosome, spindle poles, and spindle pole microtubules during mitosis and prometaphase kinetochores. It regulates dyneinmediated vesicle movement on microtubules as well as spindle assembly and cell division. ACTR1A overexpression in cells results in aberrant spindle morphologies and cell cycle delay at prometaphase, suggesting a possible function of ACTR1A/dynactin complex in progression through the prometaphase of mitosis. Species: | Reactivity: | Human, mouse and rat. | Applications: | Uses: | This antibody is useful for Peptide ELISA and Western Blot. Approx. 45kDa band observed in Human Kidney lysates (calculated MW of 42.6kDa according to NP_005727.1). | | Dilutions: | Peptide ELISA 1:1000, Western Blot 1-3 ug/ml | | Concentrations: | 0.5 mg/ml | | Positive Controls: | 2 positive controls | Packaging: | Buffer: | Tris-saline containing 0.02% Na azide (pH7.3) with 0.5% BSA | | Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. | | Preservative: | 0.02% Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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