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Description |
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Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-310840 |
NB120-17146 |
Actin Antibody (1A4+5C5)//Bovine, Guinea Pig/Mouse |
1/EA |
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문의 |
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Subject
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Actin Antibody (1A4+5C5) |
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Description
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/ Bovine, Guinea Pig/Mouse |
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Clonality
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Mono |
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Company
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Novus biologicals |
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Application
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IHC-P |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Sh, GP, Rb, Rt, Hu, Bv | | Applications: | IHC-P | | Clonality: | Monoclonal | | | Gene: | ACTA1 | | Purity: | Ascites | | Host: | Mouse | | | Specificity: | Useful in identifying tumors arising from muscle cells, i.e. leiomyosarcoma as well as rhabdomyosarcoma. | | Publications: | Antibody has not yet been mentioned in a publication. | Details: | Clone: | 1A4+5C5 | | Isotype: | IgG2a Kappa | | Immunogen: | BALB/C mice were injected with N-terminal decapeptide of alpha-smooth muscle actin for 1A4 and with purified rabbit striated muscle actin for 5C5. | | Epitope: | The two major cytoskeletal proteins implicated in ce ll motility are actin and myosin. Actin and myosin a re constituents of many ce ll types and are involved in a myriad of cellular pr ocesses including locomoti on, secretion, cytoplasmic streaming, phagocyto | | Localization: | Cytoplasmic | Gene Symbol: ACTA1 | Entrez: | 58 (Human) | | | 29437 (Rat) | | | 70 (ACTC1) | | | 72 (ACTG2) | | Related Genes: | ALB, EPR, VIM, YWHAZ, INS, CYCS, CAT, DES, NEB, ESR1, MYH14, BBS9, CD34, ACHE, TF, POMC, TPM3, MB, EXOSC10, ATP6V0A1, RFC2, RFC1, RFC4, DSC3, PLA2G4A, APOA1, AKR1A1, GLYAT, PLG, A4GALT, ELN, MPO, EPO, RPLP2, C2, C4A, CEL, HNRNPC, VDAC1, PMP2 | Background: Actins are highly conserved proteins ubiquitously expressed in all eukaryotic cells. They comprise, along with microtubules, a major component of the cytoskeleton. Actin has been found to be expressed in at least six isomeric forms. It is expressed in heart and skeletal striated muscle tissue, and in certain smooth muscle tissues, regulating contractile potentials for these cells. It is also expressed in the cytoplasm of non-muscle cells, functioning to control cell structure and motility (1). Polymerization of globular actin (G-actin) leads to a structural filament (F-actin), whose formation requires the Arp2/3 complex (2). It has been reported that actin is hyperphosphorylated in primary breast tumors (3). It has also been shown that actin dysfunction leads to certain types of heart failure (4). Species: | Reactivity: | Cross-reacts with Human, Rat, Rabbit, Cow, Guinea pig, Sheep and Snake.Not yet tested in other species. | Applications: | Uses: | IHC-P: 1/25 - 1/50. An incubation period of 30 minutes at room temperature usingf an ABC method is recommended.Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. | | Dilutions: | Immunohistochemistry-Paraffin | Packaging: | Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. | | Preservative: | Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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