랩캠퍼스(Labcampus) : [항체] - ACAT-2 Polyclonal Antibody

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ACAT-2 Polyclonal Antibody

Brand : Cayman Chemical

Cat. No	Model	Description	Unit	Price (VAT별도)	납기	재고	DataSheet	주문/견적
LCA-50-309339	100027	ACAT-2 Polyclonal Antibody//	1/EA					문의

Subject

ACAT-2 Polyclonal Antibody

Description

Clonality

Poly

Company

Cayman Chemical

Application

WB, ICC, and IHC

Conjugation

Immunogen

Contents

Information:

Synonyms

Sterol O-Acyltransferase 2

Acyl-coenzyme A: Cholesterol Acyltransferase-2

Formulation

250 ?g peptide affinity-purified IgG in 500 ?l TBS, pH 7.4, containing 50% glycerol, 0.1% BSA, and 0.02% sodium azide

Stability

1 year

Storage

-20°C

Shipping

WET ICE in continental US; may vary elsewhere

Specificity

Human ACAT-2	+
Murine ACAT-2	+
Rat ACAT-2	+
Porcine ACAT-2	+
Ovine ACAT-2	+

Correlated Keywords

Acyl-coenzyme A: cholesterol acyltransferase-2 esters ACAT2 atherosclerosis antibodies antisera antiserum western blots blotting wb icc immunocytochemistry ihc immunohistochemistry immunoblotting

Description:

Antigen: human ACAT-2 amino acids 3-20 (PGGARLRLQRTEGLGGER) · Host: rabbit · Application(s): WB, ICC, and IHC · Acyl-Coenzyme A: cholesterol acyltransferase-2 (ACAT-2) catalyzes the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A. It is associated with lipoprotein particle secretion and thus plays an important role in the metabolism of triglyceride-rich lipoproteins like ApoB100.^1,2,3 In humans, ACAT-2 is primarily expressed in the small intestine, whereas in other mammals, the enzyme is expressed in the liver and the small intestine.^4,2 Human ACAT-2 has 522 amino acid with an estimated molecular weight of 60 kDa.⁵ Cayman’s antibody detects ACAT-2 at about 60 kDa in murine liver, intestine, and fibroblasts.⁶

1 Rudel, L.L., Lee, R.G., Cockman, T.L. Acyl coenzyme A: Cholesterol acyltransferase types 1 and 2: structure and function in atherosclerosis. Curr Opin Lipidol 12 121-127 (2001).

2 Katsuren, K., Tamura, T., Arashiro, R., et al. Structure of the human acyl-CoA: Cholesterol acyltransferase-2 (ACAT-2) gene and its relation to dyslipidemia. Biochim Biophys Acta 1531 230-240 (2001).

3 Lee, R.G., Willingham, M.C., Davis, M.A., et al. Differential expression of ACAT1 and ACAT2 among cells within liver, intestine, kidney, and adrenal of nonhuman primates. J Lipid Res 41 1991-2001 (2000).

4 Cases, S., Novak, S., Zheng, Y., et al. ACAT-2, a second mammalian acyl-CoA: Cholesterol acyltransferase. Its cloning, expression, and characterization. J Biol Chem 273(4) 26755-26764 (1998).

5 Oelkers, P., Behari, A., Cromley, D., et al. Characterization of two human genes encoding acyl coenzyme A: Cholesterol acyltransferase-related enzymes. J Biol Chem 273(41) 26765-26771 (1998).

6 Anderson, R.A., Joyce, C., Davis, M., et al. Identification of a form of acyl-CoA: Cholesterol acyltransferase specific to liver and intestine in nonhuman primates. J Biol Chem 273(41) 26747-26754 (1998).

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