랩캠퍼스(Labcampus) : [항체] - Adenosine Receptor A2A Monoclonal Antibody (Clone 7FG-G5-A2)

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Adenosine Receptor A2A Monoclonal Antibody (Clone 7FG-G5-A2)

Brand : Cayman Chemical

Cat. No	Model	Description	Unit	Price (VAT별도)	납기	재고	DataSheet	주문/견적
LCA-50-309343	10011454	Adenosine Receptor A2A Monoclonal Antibody (Clone 7FG-G5-A2)//	1/EA					문의

Subject

Adenosine Receptor A2A Monoclonal Antibody (Clone 7FG-G5-A2)

Description

Clonality

Mono

Company

Cayman Chemical

Application

Conjugation

Immunogen

Contents

Information:

Synonyms

A2AR

Formulation

500 ?g affinity-purified IgG2a in 500 ?l PBS, pH 7.2, containing 50% glycerol, 0.5 mg/ml BSA, and 0.02% sodium azide

Stability

1 year

Storage

-20°C

Shipping

Wet Ice in continental US; may vary elsewhere

Specificity

+	human A2AR

Correlated Keywords

antibodies antiserum receptors WB western blots blotting immunoblotting

Description:

Antigen: human full length A2AR; the antibody recognizes amino acids 213-220 (SQPLPGER) as determined by epitope mapping · Clone designation: clone 7FG-G5-A₂ · Host: mouse · Application(s): WB · Adenosine receptor A2A Monoclonal Antibody (A2AR) is a multi-pass membrane protein that is normally localized to the plasma membrane.¹ This receptor is part of the G protein-coupled receptor family that binds adenosine and serves multiple functions. Antagonists of this receptor have been targeted for the treatment of Parkinson’s disease.^2,3 Early reports found this receptor is found primarily in the brain striatum, but is also found in immune cells and other tissues as well.² A2AR is comprised of 412 amino acids with an expected molecular weight of 45 kDa.^4,1 However multiple glycosylation sites exist that may explain the retarded migration observed by western blotting (45-50 kDa).¹ This antibody has been extensively characterized and the epitope has been mapped to the third intracellular loop of the receptor.⁵

1 Piersen, C.E., True, C.D., Well, J.N. A carboxyl-terminally truncated mutant and nonglycosylated A2a adenosine receptors retain ligand binding. Mol Pharmacol 45(5) 861-870 (1994).

2 Fredholm, B.B., Chern, Y., Franco, R., et al. Aspects of the general biology of adenosine A2A signaling. Prog Neurobiol 83 263-276 (2007).

3 Ledent, C., Vaugeois, J., Schiffmann, S.N., et al. Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor. Nature 388 674-678 (1997).

4 Robeva, A.S., Woodward, R.L., Jin, X., et al. Molecular characterization of recombinant human adenosine receptors. Drug Development Research 39 243-252 (1996).

5 Rosin, D.L., Robeva, A., Woodward, R.L., et al. Immunohistochemical localization of adenosine A2A receptors in the rat central nervous system. J Comp Neurol 401 1631-186 (1998).