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Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-50-309335 |
10007820 |
5-Lipoxygenase (Phospho-Ser523) Polyclonal Antibody// |
1/EA |
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Subject
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5-Lipoxygenase (Phospho-Ser523) Polyclonal Antibody |
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Description
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Clonality
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Poly |
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Company
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Cayman Chemical |
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Application
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WB |
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Conjugation
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Immunogen
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Contents
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Information: | | Synonyms | 5-LO (Phospho-Ser523) Polyclonal Antibody | | | Formulation | Affinity-purified rabbit polyclonal antibody | | | Stability | 1 year | | | Storage | -20°C | | | Shipping | Wet ice in continental US; may vary elsewhere | | | Correlated Keywords | wb western blotting blots antibodies regulation leukotrienes asthma fibrosis atherosclerosis inflammation regulating phospho-specific immunoblotting | Description: | Antigen: phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser523 of human 5-lipoxygenase (5-LO) · Host: rabbit · Application(s): WB · The enzyme 5-lipoxygenase (5-LO) plays a key role in regulating the production of leukotrienes (LTs).1 Overproduction of LTs contributes to several diseases, most notably chronic inflammatory diseases such as asthma, fibrosis,2 and atherosclerosis. Recent work has demonstrated that the activity of 5-LO is regulated by protein kinase A (PKA) phosphorylation of serine-523 in 5-LO. Under normal conditions, this phosphorylation may be important in limiting inflammation. Abnormal signaling through cAMP and PKA, may therefore contribute to a variety of diseases, including those characterized by chronic inflammation. The phospho-specific antibody to Ser523 on 5-LO provides a valuable tool for studying the role of 5-LO regulation in diseases such as asthma, fibrosis, and atherosclerosis. | | 1 Funk, C.D. Prostaglandins and leukotrienes: Advances in eicosanoid biology. Science 294 1871-1875 (2001). 2 Wilborn, J., Bailie, M., Coffey, M., et al. Constitutive activation of 5-lipoxygenase in the lungs of patients with idiopathic pulmonary fibrosis. J Clin Invest 97 1827-1836 (1996). | |
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