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Cat. No |
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Description |
Unit |
Price (VATº°µµ) |
³³±â |
Àç°í |
DataSheet |
ÁÖ¹®/°ßÀû |
LCA-50-309472 |
10233 |
FABP3 Monoclonal Antibody (Clone CC68)// |
1/EA |
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Subject
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FABP3 Monoclonal Antibody (Clone CC68) |
Description
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Clonality
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Mono |
Company
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Cayman Chemical |
Application
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WB |
Conjugation
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Immunogen
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Contents
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Information: | Synonyms | Cardiac FABP Fatty acid binding protein 3 Heart fatty acid binding protein H-FABP | | Formulation | 200 ?g of purified IgG2b in 500 ?L PBS, pH 7.2, containing 50% glycerol, 0.1% BSA and 0.02 % sodium azide | | Stability | 1 year | | Storage | -20¡ÆC | | Shipping | Wet Ice in continental US; may vary elsewhere | | Specificity | Human FABP3 | + | Rat FABP3 | + | Murine FABP3 | - | Murine FABP1 | - | Murine FABP2 | - | Murine FABP4 | - | Murine FABP5 | - | | | Correlated Keywords | antibody antisera antiserum antibodies wb western blots immunoblotting small endogenous exogenous lipophilic ligands uptake metabolism cellular membranes levels intracellular trafficking substrates modulation enzymes lipid metabolic pathways cells growth differentiation antiparallel .beta. strands barrel cytosolic tissues biomarker myocardial injury infarction atherosclerosis endocrinology blotting | Description: Antigen: synthetic peptide from human FABP3 amino acids 44-55 · Host: mouse · Isotype: IgG2b · Application(s): WB · Peptide sequence: EKNGDILTLKTH · Fatty acid binding protein 3 (FABP3) is one of nine known cytosolic FABPs ranging in size from 14-15 kDa containing 127-132 amino acids.1 Members of this protein family exhibit high affinity for small lipophilic ligands and were named according to the tissue from which they were initially isolated.1 Studies suggest that FABPs are involved in the uptake and metabolism of fatty acids, in the maintenance of cellular membrane fatty acid levels, in intracellular trafficking of these substrates, in the modulation of specific enzymes of lipid metabolic pathways, and in the modulation of cell growth and differentiation.2 FABP family members have highly conserved three dimensional structures and 22-73% amino acid sequence similarity. FABP3 is composed of ten antiparallel ¥â strands that form a barrel and is the most widely distributed FABP. It is found in heart, skeletal and smooth muscle, mammary epithelial cells, aorta, distal tubules of the kidney, lung, brain, placenta, and ovary. FABP3 is a potential biomarker for myocardial injury, especially for early detection of acute myocardial infarction (AMI).1 | 1 Zimmerman, A.W., Veerkamp, J.H. New insights into the structure and function of fatty acid-binding proteins. Cell Mol Life Sci 59 1096-1116 (2002). 2 Massolini, G., Calleri, E. Survey of binding properties of fatty acid-binding proteins chromatographic methods. J Chromatogr B 797 255-268 (2003). | |
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