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Description |
Unit |
Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-311402 |
NB100-78535 |
B Raf [phospho Thr598/Ser601] Antibody//Human/Rabbit |
1/EA |
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문의 |
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Subject
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B Raf [phospho Thr598/Ser601] Antibody |
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Description
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/ Human/Rabbit |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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IF |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Protein Type: | Peptide | | Species: | Hu | | Applications: | IF | | Clonality: | Polyclonal | | | Gene: | BRAF | | Purity: | Immunogen affinity purified | | Host: | Rabbit | | | Specificity: | B-Raf [Thr598/Ser601] | | Publications: | Antibody has not yet been mentioned in a publication. | Details: | Modification: | phospho Thr598/Ser601 | | Isotype: | IgG | | Immunogen: | Modified peptide | Gene Symbol: BRAF | Entrez: | 673 (Human) | | Related Genes: | RAF1, MAPK1, ZHX2, EPHB2, KRAS, CDKN2A, HRAS, MAPK3, TP53, EGFR, NRAS, MAP2K1, MLH1, SNRPE, PIK3CG, PIK3CA, AKT1, RET, MAP2K2, PTEN, CTNNB1, MAPK12, ARAF, RAP1A, CDKN1A, MSH2, TERF2IP, APC, EGF, CCND1, ERBB2, PROC, CDK4, PIK3CB, PIK3CD, RASSF1, MGMT, TCEAL1, D4S234E, PKA | Background: The Raf proteins are a family of serine/threonine-specific kinases that serve as a central intermediate in transmitting extracellular signals to the mitogen-activated protein kinase cascade, which controls cell growth, differentiation and survival. Three isoforms of Raf proteins have been found in mammalian cells: Raf-1, A-Raf and B-Raf. The B-raf involved in signal transduction from the membrane to the nucleus. It has been reported that T598 and S601 are the major phosphorylation sites of B-Raf in response to oncogenic Ras, and phosphorylation of these two residues is required for full activation of B-Raf. Mutations in the B-Raf gene have been reported in a number of human cancers, including malignant melanoma, thyroid cancer, and colorectal carcinoma. The poly6327 antibody recognizes human phosphorylated B-Raf (Thr598/Ser601) and has been shown to be useful for immunoflorence staining. Species: Applications: | Uses: | Each lot of this antibody is quality control tested by Immunofluorescence staining. For immunofluorescence microscopy, suggested working dilution(s): Use a dilution range of 1:100~1:400. It is recommended that the reagent be titrated for optimal performance for each application. | | Dilutions: | immunofluorescence | | Positive Controls: | 1 positive controls | Packaging: | Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and | | Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. | | Preservative: | 0.09% Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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