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Description |
Unit |
Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-310217 |
NBP1-21426 |
AATF Antibody//Human, Mouse/Rabbit |
1/EA |
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문의 |
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Subject
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AATF Antibody |
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Description
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/ Human, Mouse/Rabbit |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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IHC-P |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Mu, Hu | | Applications: | IHC-P | | Clonality: | Polyclonal | | | Gene: | AATF | | Purity: | Whole antisera | | Host: | Rabbit | | | Specificity: | Recognizes human Apoptosis Antagonizing Transcription Factor (AATF), also known as Che-1, a ubiquitously expressed nuclear protein. Research indicates that AATF functions as a general inhibitor of the histone deacetylase HDAC1. It has been also demonstrated that AATF activates transcription factor E2F and that it is involved in the activation of anti-apoptotic pathways. AATF has been shown to protect neural cells against oxidative damage suggesting it may have therapeutic uses in Alzheimer's Disease. This antibody has been reported to work in western blotting. | Details: | Isotype: | IgG | | Immunogen: | Synthetic Peptide corresponding to a 12 amino acid sequence near the C-terminus of human AATF. | Gene Symbol: AATF | Entrez: | 26574 (Human) | | Related Genes: | CASP8, FADD, CASP9, FAS, CFLAR, PEA15, TP53, DEDD, CASP10, AKR1C2, CDKN1A, ATP2A2, TNF, MAP3K12, ATM, CHE2, TNFSF10, RYBP, CASP3, AR, DLK1, BCHE, TCEAL1, BLOC1S2, MAPK1, MAGED1, CHEK2, APAF1, FASLG, D4S234E, PAK3, TFRC, MAPT, NFKB1, ATR, DAP, FCN2, BCL2L1, HP, EPHB2 | Background: AATF (Apoptosis-antagonizing transcription factor), also termed Che-1, was identified as interacting protein of Dlk/ZIP kinase and RNA polymerase II. AATF has additionally been shown to bind Rb, thereby activating transcription factor E2F and promoting cell cycle progression. AATF enhances steroid receptor-mediated transactivation in a hormone and dose-dependent manner. It is involved in the activation of anti-apoptotic pathways. AATF contains an extremely acidic domain, a putative leucine zipper and a nuclear localization signal, features which are characteristic of transcription factors. Recently AATF has been shown to protect neural cells against oxidative damage suggesting it may have therapeutic uses in Alzheimer's Disease. Species: | Reactivity: | Human and Mouse. | Applications: | Uses: | Immunohistochemistry-Paraffin This product does not require protein digestion pre-treatment of paraffin sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections. | | Dilutions: | Immunohistochemistry-Paraffin 2.5ug/ml | Packaging: | Buffer: | PBS | | Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. | | Preservative: | 0.02% Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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