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Description |
Unit |
Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-310259 |
NB100-305C |
53BP1 Antibody [DyLight 649]//Human, Mouse/Rabbit |
1/EA |
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문의 |
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Subject
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53BP1 Antibody [DyLight 649] |
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Description
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/ Human, Mouse/Rabbit |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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ICC, Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Mu, Hu | | Applications: | ICC, WB | | Clonality: | Polyclonal | | | Gene: | TP53BP1 | | Purity: | Immunogen affinity purified | | Host: | Rabbit | | | Specificity: | NB100-305 is specific for human 53BP1 protein. | | Publications: | Antibody has been mentioned in at least 8 publications. | Details: | Conjugate: | DyLight 649 | | Immunogen: | The epitope recognized by this antibody maps to a region between residues 1925 and the C-terminus (residue 1972) of human tumor protein p53 binding protein 1 using the numbering given in entry NP_005648.1 (GeneID 7158). | Gene Symbol: TP53BP1 | Entrez: | 7158 (Human) | | Swiss Prot: | NP_005648.1 (Human) | | Related Genes: | H2AFX, ATM, TP53, MDC1, NBN, BRCA1, ATR, MMAB, ANTXR1, MRE11A, CHEK2, NLRP2, CDKN1A, CHEK1, TERF2, ARTN, RAD9A, RAD51, CRB2, JUN, E2F1, PRKDC, RAD50, TCEAL1, NFKB1, D4S234E, RB1, RNF8, FOS, DCLRE1C, DDR1, TP53BP2, BLM, UBE2N, TBPL1, CDKN2A, HEPACAM, PAXIP1, MDM2, IFI16 | Background: P53-binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes to the presumptive sites of damage, specifically, double-strand breaks. This also suggests a role in DNA repair, maintaining genomic stability. Species: | Reactivity: | Human in Western Blot and immunocytochemistry/immunofluorescence. Mouse in immunocytochemistry/immunofluorescence (Western Blot has not been done using this antibody on Mouse protein). | Applications: | Uses: | This antibody is useful for: Western Blot: 1:2,000 - 1:10,000, and Immunocytochemistry: 1:200 to 1:1,000 | | Dilutions: | Western Blot 1:200- 1:10000, Immunocytochemistry 1:200-1:1000, | | Concentrations: | 1.0 mg/ml | | Conjugated Ab's: | 4 conjugated antibodies | Packaging: | Buffer: | PBS | | Storage: | Store at 4C. Do not freeze. | | Preservative: | No Preservative | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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