랩캠퍼스(Labcampus) : [항체] - 200kDa Neurofilament Heavy Antibody

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200kDa Neurofilament Heavy Antibody

Brand : Novus biologicals

Cat. No	Model	Description	Unit	Price (VAT별도)	납기	재고	DataSheet	주문/견적
LCA-23-310303	NBP1-05211	200kDa Neurofilament Heavy Antibody//Human, Rat/Mouse	1/EA					문의

Subject

200kDa Neurofilament Heavy Antibody

Description

/ Human, Rat/Mouse

Clonality

Mono

Company

Novus biologicals

Application

IF, Western Blot

Conjugation

Immunogen

Contents

Description:Summary:

Species:	Rt, Hu
Applications:	WB, IF
Clonality:	Monoclonal

Gene:	NEFH
Purity:	Ascites
Host:	Mouse

Specificity:	It recognizes phosphorylated NF-H KSP (lysine-serine-proline) type sequences. In some species there is some cross-reactivity with the related phosphorylated KSP sequences found in the related neurofilament subunit NF-M. The recognizes NF-H strongly in all mammals tested to date and also in chicken. It recognizes neurofilaments in frozen sections in tissue culture and in formalin fixed sections.
Publications:	Antibody has not yet been mentioned in a publication.

Details:

Gene Symbol: NEFH

Entrez:	4744 (Human)
	24587 (Rat)
Related Genes:	NEFM, NEFL, NFASC, SOD1, PRPH, GFAP, LDLR, FH, CFH, MAP2, MAPT, IGFALS, NES, REN, PRNP, AGT, MBP, UCHL1, METAP2, ACHE, HOXA9, MT1M, MAPK1, VIM, CLDN6, IL6, PSEN1, GPR158, PSEN2, RSPO4, PKP1, CDK5, ATP2A2, GAP-43, RANGAP1, MAPK9, CA3, SLC17A5, TAC1, LIF

Background: Neurofilaments are the 10nm or intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. NF-H is the neurofilament high or heavy molecular weight polypeptide and runs on SDS-PAGE gels at 200-220 kDa, with some variability across species boundaries. Antibodies to NF-H are useful for identifying neuronal cells and their processes in tissue sections and in tissue culture. NF-H antibodies can also be useful in the diagnostics of neurofilament accumulations seen in many neurological diseases, such as Amyotrophic Lateral Sclerosis (also known as Lou Gehrig's disease) and Alzheimer's disease. NBP1-05211 is one of numerous antibodies which reacts preferentially with the axonal phosphorylated forms of NF-H. Interestingly these phosphorylated forms of NF-H are normally restricted to axons, while less phosphorylated forms are found in dendrites. However in numerous damage and disease states, phosphorylated NF-H can be detected with NBP1-05211 in dendritic and perikaryal neurofilaments. Species:

Reactivity:

Human and Rat

Applications:

Uses:	Immunofluorescence and Western Blot
Dilutions:	immunofluorescence 1:1000, Western Blot 1:10000

Packaging:

Storage:	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Preservative:	No Preservative
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.