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Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-310341 |
NB100-1964 |
14-3-3 zeta/delta Antibody (22-IID8B)//Bovine, Canine/Mouse |
1/EA |
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Subject
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14-3-3 zeta/delta Antibody (22-IID8B) |
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Description
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/ Bovine, Canine/Mouse |
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Clonality
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Mono |
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Company
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Novus biologicals |
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Application
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ICC, IHC-P, Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Sh, Rb, Rt, Mk, Mu, Hu, Ca, Bv | | Applications: | ICC, WB, IHC | | Clonality: | Monoclonal | | | Gene: | YWHAZ | | Purity: | protein G purified | | Host: | Mouse | | | Specificity: | 14-3-3 beta + zeta (22-IID8B) | | Publications: | Antibody has not yet been mentioned in a publication. | Details: | Clone: | 22-IID8B | | Isotype: | IgG | | Immunogen: | Lysed transformed amnion cells (AMA) (Human). | | Localization: | Cytoplasmic | Gene Symbol: YWHAZ | Entrez: | 7534 (Human) | | Related Genes: | PLA2G2A, PLA2G6, PLA2G1B, PLA2G4A, TNF, PKC, ALB, KNG1, HSPG2, KAT5, CD19, PTGS2, PLA2G10, ANXA1, PLEKHM1, F2, INS, KIAA0101, EGF, PLA2G7, ALOX5, CAT, AGT, IL6, MAPK1, LPL, C4A, PCSK7, POMC, IL1B, TH, DAG1, MPO, IL2, TXA2, AVP, EXOSC10, ADCY7, MAPK3, PLCB4 | Background: 14-3-3 proteins are highly conserved proteins which play a role in both signal transduction and progression through the cell cycle by binding to and regulating several different proteins. 14-3-3 proteins activate tyrosine and tryptophan hydroxylases and protein kinase C. They mediate signal transduction by binding to phosphoserine-containing proteins. There are at least 7 mammalian isoforms: alpha, beta, gamma, delta, epsilon, zeta, and eta. An eighth subtype, termed theta has been found in rat brain. The 14-3-3 proteins exist in vitro and in vivo as either homo- or heterodimers which interact via their N-terminal domains and are subject to phosphorylation by protein kinase C. 14-3-3 proteins are localized in the cytoplasm of neurons in the cerebral cortex and are axonally transported to the nerve terminals. They may be present at lower levels in various other eukaryotic tissues. Northern blot analysis has shown expression of the eta chain in cultured cell lines derived from various tumors. Species: | Reactivity: | Cross-reacts with Human, Mouse, Rat, Cow, Dog, Monkey, Pig, Rabbit and Sheep. Not yet tested in other species. | Applications: | Uses: | Predicted molecular weight: 29 and 30 kDa. Optimal dilutions/concentrations should be determined by the end user. | | Dilutions: | immunohistochemistry 1/50, Western Blot 1 ug/ml, Immunocytochemistry | | Concentrations: | 1.0 mg/ml | | Positive Controls: | 2 positive controls | Packaging: | Buffer: | Preservative: None Constituents: 50% Glycerol, PBS, 0.1mM PMSF. pH 7.2 | | Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. | | Preservative: | No Preservative | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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