|
| |
| Cat. No |
Model |
Description |
Unit |
Price
(VAT별도) |
납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-310327 |
NB100-92416 |
14-3-3 sigma Antibody//Human, Mouse/Rabbit |
1/EA |
|
|
|
|
문의 |
|
|
|
|
|
|
|
Subject
|
14-3-3 sigma Antibody |
|
Description
|
/ Human, Mouse/Rabbit |
|
Clonality
|
Poly |
|
Company
|
Novus biologicals |
|
Application
|
ELISA, Western Blot |
|
Conjugation
|
|
|
Immunogen
|
|
|
Contents
|
Description:Summary: | Species: | Mu, Hu | | Applications: | WB, ELISA | | Clonality: | Polyclonal | | | Gene: | SFN | | Purity: | Immunogen affinity purified | | Host: | Rabbit | | | Specificity: | 14-3-3 sigma (E66) detects endogenous levels of 14-3-3 sigma (E66) protein. | Details: Gene Symbol: SFN | Entrez: | 2810 (Human) | | Related Genes: | TP53, CDKN1A, REXO2, CDKN2A, TCEAL1, D4S234E, MMP1, PAK3, YWHAQ, NFE2L2, AKT1, SLC12A9, MAPK1, TP63, CKAP4, TH, PTGS2, CCNB1, CDH1, BCL2, CASP3, TRIM25, GABPA, GSTP1, EGFR, SERPINB3, RARB, JUN, RASSF1, MMP3, CCND1, CDC2, MSLN, ERBB2, ESR1, BAX, PCNA, HDAC9, YWHAZ, MAPK8 | Background: 14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms comprise this family of signaling intermediates, denoted 14-3-3 beta, gamma, episilon, zeta, theta, nu and sigma. 14-3-3 proteins form dimers that present two binding sites for ligand proteins, thereby bringing together two proteins that may not otherwise associate. These ligands largely share a 14-3-3 consensus binding motif and exhibit serine/threonine phosphorylation. 14-3-3 proteins function in broad regulation of these ligand proteins, by cytoplasmic sequestration, occupation of interaction domains and import/export sequences, prevention of degradation, activation/repression of enzymatic activity, and facilitation of protein modification, and thus loss of expression contributes to a vast array of pathogenic cellular activity. Species: | Reactivity: | This antibody is reactive against Human, Mouse. | Applications: | Uses: | Western blot analysis of 14-3-3 sigma (E66) antibody in extracts from HT-29 cells. | | Dilutions: | ELISA 1:10000-1:20000, Western Blot 1:500-1:1000, | | Concentrations: | 1.0 mg/ml | | Positive Controls: | 1 positive controls | Packaging: | Buffer: | Phosphate buffered saline, pH 7.2. | | Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. | | Preservative: | 15mM Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
|
|
|
|
