|
|
Cat. No |
Model |
Description |
Unit |
Price (VATº°µµ) |
³³±â |
Àç°í |
DataSheet |
ÁÖ¹®/°ßÀû |
LCA-23-310343 |
NB100-97861 |
14-3-3 sigma Antibody//Human/Rabbit |
1/EA |
|
|
|
|
¹®ÀÇ |
|
|
|
|
|
|
Subject
|
14-3-3 sigma Antibody |
Description
|
/ Human/Rabbit |
Clonality
|
Poly |
Company
|
Novus biologicals |
Application
|
IHC-P |
Conjugation
|
|
Immunogen
|
|
Contents
|
Description:Summary: Species: | Hu | Applications: | IHC-P | Clonality: | Polyclonal | | Gene: | SFN | Purity: | Immunogen affinity purified | Host: | Rabbit | | Specificity: | 14-3-3 Sigma | Details: Isotype: | IgG | Immunogen: | The epitope recognized by this antibody maps to a region between residue 198 and 248 of human 14-3-3 sigma using the numbering given in entry NP_006133.1 (GeneID 2810). | Gene Symbol: SFN Entrez: | 2810 (Human) | Swiss Prot: | NP_006133.1 (Human) | Related Genes: | TP53, CDKN1A, REXO2, CDKN2A, TCEAL1, D4S234E, MMP1, PAK3, YWHAQ, NFE2L2, AKT1, SLC12A9, MAPK1, TP63, CKAP4, TH, PTGS2, CCNB1, CDH1, BCL2, CASP3, TRIM25, GABPA, GSTP1, EGFR, SERPINB3, RARB, JUN, RASSF1, MMP3, CCND1, CDC2, MSLN, ERBB2, ESR1, BAX, PCNA, HDAC9, YWHAZ, MAPK8 | Background: 14-3-3 sigma was identified as an epithelial cell marker. It is part of the 14-3-3 family of proteins in which seven isoforms have been identified: beta, zeta, gamma, eta, epsilon, tau, and sigma. 14-3-3 proteins function as adaptors that bind with a number of partners to mediate various signaling pathways. 14-3-3 sigma is also called stratifin or HME1 and appears to function as a tumor suppressor whose expression can be downregulated via methylation. Loss of 14-3-3 sigma expression results in a defective G2/M phase checkpoint and appears to contribute to both epithelial and non-epithelial tumorigenesis. Alternate names for 14-3-3 sigma include epithelial marker protein 1, SFN and YWHAS. Species: Applications: Uses: | This antibody is useful for Formalin-Fixed Paraffin-Embedded Tissue. | Dilutions: | Immunohistochemistry-Paraffin 1:100-1:500, | Positive Controls: | 1 positive controls | Packaging: Buffer: | Tris-buffered Saline containing 0.1% BSA | Storage: | Store at 4C. Do not freeze. | Preservative: | 0.09% Sodium Azide | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
|
|
|
|