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Cat. No |
Model |
Description |
Unit |
Price (VATº°µµ) |
³³±â |
Àç°í |
DataSheet |
ÁÖ¹®/°ßÀû |
LCA-23-310346 |
NB100-668 |
14-3-3 [phospho Ser58] Antibody//Human, Mouse,/Rabbit |
1/EA |
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Subject
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14-3-3 [phospho Ser58] Antibody |
Description
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/ Human, Mouse,/Rabbit |
Clonality
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Poly |
Company
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Novus biologicals |
Application
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Western Blot |
Conjugation
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Immunogen
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Contents
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Description:Summary: Species: | Xp, Rt, Mu, Hu | Applications: | WB | Clonality: | Polyclonal | | Gene: | YWHAQ | Purity: | Affinity purified | Host: | Rabbit | | Specificity: | 14-3-3 Protein [Ser58] | Publications: | Antibody has not yet been mentioned in a publication. | Details: Modification: | phospho Ser58 | Immunogen: | Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser58 of rat 14-3-3 protein. | Gene Symbol: YWHAQ Entrez: | 10971 (Human) | Related Genes: | MAPT, TH, AKT1, PRNP, LAMC2, RAF1, MAPK1, CDC25C, PIK3CG, BCL2L1, PTK2B, CHEK1, GSTP1, ZHX2, PKA, HCLS1, MAPK8, CASP3, ZCCHC6, SPTB, MAPK3, RASGRF1, SNCA, CDK5, SRC, BCL2, PKC, EGF, INS, CDC2, APP, MAP3K5, MAPK14, GRN, PPP2R4, EPHB2, PIK3CA, PIK3CB, PIK3CD, TP53 | Background: 14-3-3 proteins are a family of highly conserved proteins that appear to have multiple roles in cell signaling. The proteins are abundantly expressed in the brain and have been detected in the cerebrospinal fluid of patients with different neurological disorders. 14-3-3 proteins bind protein ligands that are typically phosphorylated on serine or threonine residues and regulate the functions of these binding partners by a number of different mechanisms. The 14-3-3 proteins affect a diverse array of cellular processes including the cell cycle and transcription, signal transduction and intracellular trafficking. These functions of 14-3-3 proteins are facilitated by, if not dependent on, its dimeric structure. Recent work has demonstrated that the dimeric status of the 14-3-3 protein is regulated by site-specific serine phosphorylation. (1-5) Species: Reactivity: | Human, mouse, Xenopus, and rat based on 100% antigen sequence homology. | Applications: Uses: | This antibody has been tested in Western blot on rat brain hippocampal lysate, detecting a band ~29 kDa. No other applications have been tested. *The investigator should determine the optimal working dilution for a specific application. | Dilutions: | Western Blot 1:1,000 | Positive Controls: | 1 positive controls | Packaging: Buffer: | 10 mM Hepes (pH7.5), 150 mM NaCl, 100 ug/ml BSA and 50% glycerol | Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. | Preservative: | No Preservative | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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