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| Cat. No |
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Description |
Unit |
Price
(VAT별도) |
납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-310349 |
NB100-81672 |
14-3-3 sigma Antibody//Human/Rabbit |
1/EA |
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문의 |
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Subject
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14-3-3 sigma Antibody |
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Description
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/ Human/Rabbit |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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IP, Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Hu | | Applications: | IP, WB | | Clonality: | Polyclonal | | | Gene: | SFN | | Purity: | Affinity purified | | Host: | Rabbit | | | Specificity: | 14-3-3 Sigma | Details: | Isotype: | IgG | | Immunogen: | The epitope recognized by this antibody maps to a region between residue 198 and 248 of human 14-3-3 sigma using the numbering given in entry NP_006133.1 (GeneID 2810). | Gene Symbol: SFN | Entrez: | 2810 (Human) | | Swiss Prot: | NP_006133.1 (Human) | | Related Genes: | TP53, CDKN1A, REXO2, CDKN2A, TCEAL1, D4S234E, MMP1, PAK3, YWHAQ, NFE2L2, AKT1, SLC12A9, MAPK1, TP63, CKAP4, TH, PTGS2, CCNB1, CDH1, BCL2, CASP3, TRIM25, GABPA, GSTP1, EGFR, SERPINB3, RARB, JUN, RASSF1, MMP3, CCND1, CDC2, MSLN, ERBB2, ESR1, BAX, PCNA, HDAC9, YWHAZ, MAPK8 | Background: 14-3-3 sigma was identified as an epithelial cell marker. It is part of the 14-3-3 family of proteins in which seven isoforms have been identified: beta, zeta, gamma, eta, epsilon, tau, and sigma. 14-3-3 proteins function as adaptors that bind with a number of partners to mediate various signaling pathways. 14-3-3 sigma is also called stratifin or HME1 and appears to function as a tumor suppressor whose expression can be down regulated via methylation. Loss of 14-3-3 sigma expression results in a defective G2/M phase checkpoint and appears to contribute to both epithelial and non-epithelial tumorigenesis. Alternate names for 14-3-3 sigma include epithelial marker protein 1, SFN and YWHAS. Species: Applications: | Uses: | Western blot and Immunoprecipitation | | Dilutions: | Western Blot 1:2000-1:10000, immunoprecipitation 2-5 mcg/mg lysate | | Concentrations: | 1.0 mg/ml | | Positive Controls: | 1 positive controls | Packaging: | Buffer: | Tris-citrate/phosphate buffer, pH 7 to 8 | | Storage: | Store at 4C. Do not freeze. | | Preservative: | 0.09% Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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