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Description |
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Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-310379 |
NB100-1524 |
5HT2C Receptor Antibody//Human/Goat |
1/EA |
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문의 |
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Subject
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5HT2C Receptor Antibody |
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Description
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/ Human/Goat |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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PEP-ELISA, Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Hu | | Applications: | WB, PEP-ELISA | | Clonality: | Polyclonal | | | Gene: | HTR2C | | Purity: | Immunogen affinity purified | | Host: | Goat | | | Specificity: | This is specific for Serotonin receptor 2C / HTR2C | | Publications: | Antibody has been mentioned in at least 1 publication. | Details: | Isotype: | IgG | | Immunogen: | Synthetic peptide with sequence C-QVENLELPVN, representing the internal region of the human protein according to NP_000859.1 | | Epitope: | internal region | Gene Symbol: HTR2C | Entrez: | 3358 (Human) | | Swiss Prot: | NP_000859.1 (Human) | | Related Genes: | HTR2A, HTR1A, HTR1B, HTR2B, SLC6A4, HTR7, HTR4, 5-HT3, HTR6, POMC, HTR1D, PRL, DRD4, DIO2, TPH1, MAOA, BBS9, DIO3, LMOD1, HTR1F, HTR5A, HTR1E, BDNF, DRD3, NPY, TNFRSF11A, DRD2, SLC6A3, CRH, ARHGDIB, LEP, GT, ATP7A, MVK, MDK, COMT, CYP2D6, NF2, HSPG2, HTR5B | Background: Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine neurotransmitter synthesised in serotonergic neurons in the central nervous system and enterochromaffin cells in the gastrointestinal tract. Serotonin plays an important part in the biochemistry of depression, migraine, bipolar disorder and anxiety. It is also believed to be influential on sexuality and appetite. 5-HT is generally thought not to be released from synaptic terminal buttons in the manner of classical neurotransmission but from serotonergic varacosities into the extra neuronal space. From here it is free to diffuse over a relatively large region of space (>20?m) and activate 5-HT receptors located on the dendrites, cell bodies and presynaptic terminals of adjacent neurons. Serotonergic action is terminated primarily via uptake of 5-HT from the synapse. This is through the specific monoamine transporter for 5-HT, 5-HT reuptake transporter, on the presynaptic neuron. The pharmacology of 5-HT is extremely complex, with its actions being mediated by a large and diverse range of 5-HT receptors. Species: | Reactivity: | Human, Mouse, Rat and Dog. | Applications: | Uses: | This antibody is useful for Peptide ELISA and Western Blot. Approx 50kDa band observed in lysates of Human EBV immortalised Lymphoblastoids, T cell MOLT4 and monocytic cell line U937 (calculated MW of 51.8kDa according to NP_000859.1). | | Dilutions: | Peptide ELISA 1:64000, Western Blot 1-3?g/ml | | Concentrations: | 0.5 mg/ml | Packaging: | Buffer: | Tris saline containing 0.02% sodium azide, pH7.3 with 0.5% BSA | | Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. | | Preservative: | 0.02% Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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