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Description |
Unit |
Price
(VAT별도) |
납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-310390 |
NLS652 |
5HT6 Receptor Antibody//Human/Rabbit |
1/EA |
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문의 |
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Subject
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5HT6 Receptor Antibody |
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Description
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/ Human/Rabbit |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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IHC-P |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Hu | | Applications: | IHC | | Clonality: | Polyclonal | | | Gene: | HTR6 | | Purity: | Immunogen affinity purified | | Host: | Rabbit | | | Specificity: | 5-HT6 Receptor | Details: | Immunogen: | Synthetic peptide [KLH conjugated] made to the C-term | | Localization: | Multi pass membrane protein. | Gene Symbol: HTR6 | Entrez: | 3362 (Human) | | Related Genes: | HTR7, HTR2A, HTR1A, HTR4, HTR2C, HTR1B, 5-HT3, HTR2B, ADCY7, HTR1D, HTR5A, HTR1F, TNFRSF11A, HTR1E, CALR, SLC6A4, HTR5B, ARHGDIB, DIO3, BBS9, LMOD1, DIO2, FOS, SLC6A3, ACHE, DRD2, TPH1, COMT, PRL, HTR3A, NR1I2, GPR151, MAOA, MRGPRX1, GPBAR1, BDNF, CYSLTR2, LGR6, OXER1, DRD4 | Background: 5-HT6, a Serotonin Receptor, appears to regulate cholinergic neurotransmission in the brain rather than the expected interaction as a modulator of dopaminergic transmission. This interaction predicts a possible role for 5-HT6 Receptor antagonists in the treatment of learning and memory disorders. The 5-HT6 Receptor is abundant in limbic areas, which participate in the control of mood and emotion. Some antidepressants and antipsychotics are potent 5-HT6 Receptor antagonists, making this gene valuable for the pharmaceutical industry. 5-HT6 may be involved in the pathogenesis of mood disorders, schizophrenia, in Alzheimer's disease. A splice variant that has a 289bp deletion in the transmembrane region IV and the third intracellular loop has been isolated. 5-HT6 Receptor has been reported primarily in striatum of the brain. Expression has also been seen in stomach, spinal cord, and the lymphoid tissues of rats, including peripheral blood lymphocytes, spleen, and thymus. ESTs have been isolated from brain libraries. Species: | Reactivity: | Human. There is 100 % rat identity and 100 % rat homology. There is 94 % mouse identity and 100 % mouse homology. | Applications: | Uses: | Optimal dilutions should be determined by the end user. | | Dilutions: | immunohistochemistry 10-20 ug/ml | | Concentrations: | 1.0 mg/ml | | Positive Controls: | 1 positive controls | Packaging: | Buffer: | PBS [pH7.7] | | Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. | | Preservative: | 0.01% Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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