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Description |
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Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-310392 |
NB100-56352 |
5HT7 Receptor Antibody//Canine, Human/Rabbit |
1/EA |
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Subject
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5HT7 Receptor Antibody |
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Description
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/ Canine, Human/Rabbit |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Rt, Mu, Hu, Ca | | Applications: | WB | | Clonality: | Polyclonal | | | Gene: | HTR7 | | Purity: | protein G purified | | Host: | Rabbit | | | Specificity: | In human brain, a 50 kDa band is observed. Both 45 kDa and 50 kDa bands have been observed in various human glioblastoma cell lines and in the human microglial MC-3 cell lines. Bands in the 45-50 kDa range correspond to the predicted molecular weight for the 5HT7 receptor. The 5HT7 receptor also has putative sites for N-linked glycosylation and phosphorylation which may lead to variations in observed molecular weights. The 5HT7 antibody recognizes all described 5HT7 receptor splice variants. | | Publications: | Antibody has been mentioned in at least 3 publications. | Details: | Isotype: | IgG | | Immunogen: | This antibody was developed by immunizing rabbits with a mixture of synthetic peptides corresponding to amino acids 13-28 of the rat 5-HT7R(Genbank Accession no. AAA42134.1). This sequence is identical for 5-HT7R splice variants in the rat (5-HT7Ra/b/c), human (5-HT7Ra/b/d) and human 5-HT7, the mouse 5-HT7R. It is 93% conserved with dog 5-HT7Ra/b, and 81% conserved with pig 5-HT7R. | Gene Symbol: HTR7 | Related Genes: | HTR1A, HTR2A, HTR4, HTR6, HTR1B, HTR2C, 5-HT3, TNFRSF11A, HTR2B, ADCY7, HTR1D, HTR5A, HTR1F, SLC6A4, POMC, HTR1E, HTR5B, MAPK1, MAPK3, CA3, CA1, FOS, AVP, GPR151, MRGPRX1, LGR6, OXER1, PRL, DIO2, VN1R17P, FZD4, MRGPRX3, GLYAT, MRGPRX4, PSMC6, GPBAR1, CYSLTR2, LPAR3, CAT, GPR166P | Background: Receptors for serotonin (5-hydroxytryptamine, 5-HT) are classified into seven major classes (5-HTR1-7), based on structural, functional and pharmacological criteria (Hoyer et al, 1994). The 5-HT7 receptor (5-HT7R) is a seven-transmembrane-domain G-protein-coupled receptor that has important roles in regulating diverse biological process in the central and peripheral nervous systems (reviewed in Hedlund and Sutcliffe, 2004). Receptors for serotonin (5-hydroxytryptamine, 5-HT) are classified into seven major classes (5-HT1-7), based on structural, functional and pharmacological criteria (Hoyer et al, 1994). Sequence alignment shows a high degree of interspecies 5-HT7R homology (>90%), and a low homology with other 5-HTRs ( Species: | Reactivity: | Reacts with Dog, Human, Mouse, Rat. Predicted to react with Porcine. Not yet tested in other species. | Applications: | Uses: | This antibody is useful for Western Blot. | | Dilutions: | Western Blot 1-2 ug/ml | | Concentrations: | 0.5 mg/ml | Packaging: | Buffer: | PBS containing 0.2% gelatin | | Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. | | Preservative: | 0.05% Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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