랩캠퍼스(Labcampus) : [항체] - I Kappa B alpha (IKBa)

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I Kappa B alpha (IKBa)

Brand : Acris Antibodies GmbH

Cat. No	Model	Description	Unit	Price (VAT별도)	납기	재고	DataSheet	주문/견적
LCA-24-356910	AP07862SU-N	I Kappa B alpha (IKBa)//Human/Rabbit	1/EA					문의

Subject

I Kappa B alpha (IKBa)

Description

/ Human/Rabbit

Clonality

Mono

Company

Acris Antibodies GmbH

Application

Enzyme Immunoassay, Immunofluorescence, Paraffin Sections, Western blot / Immunoblot, Immunoprecipit

Conjugation

Immunogen

Contents

Description:

Manufacturer	Acris Antibodies GmbH
Quantity	50 ul
Reactivity	Human
Applications	Enzyme Immunoassay, Immunofluorescence, Paraffin Sections, Western blot / Immunoblot, Immunoprecipitation
Host	Rabbit
PDF datasheet	view
Shipping to	Not USA/Canada

Synonyms	NFKBIA, IKBA, MAD3, NFKBI, NF-kappa-B inhibitor alpha, I-kappa-B-alpha, IkappaBalpha, IkB-alpha
Swiss Prot Num	P25963
Immunogen	IkBa peptide corresponding to a region near the C-terminus of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH).
Product Type	Antibodies
Storage	Store the antibody (in aliquots) at -20°C for short term or at -70°C for long term. Dilute only prior to immediate use. Avoid cycles of freezing and thawing. Shelf life: One year from despatch.
Format	State: Liquid purified IgG fraction.
?	Purification: Delipidation and Defibrination.
?	Buffer System: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.1% (w/v) Sodium Azide as preservative.
Specificity	This antibody recognises Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-cells Inhibitor, Alpha (NFKBIA).
Application	Immunohistochemistry on Paraffin Sections (1/1000). Immunoprecipitation. Immunofluorescence. Western Blot. ELISA.
Background	Three major forms of IKB like molecules have been identified and each is characterised by multiple copies of ankyrin repeats. IKB alpha and IKB beta appear to be the major regulatory forms of IKB in most cells. These proteins interact with p65 or cRel containing forms of NFkB and block nuclear import by masking the nuclear localisation sequences of NFkB. The activation of NFkB involves the inducible phosphorylation and subsequent degradation of IKB. Immunoblotting easily detects the hyperphosphorylated forms of IKB alpha, but not phosphorylated IKB beta. Interestingly, IKB alpha and IKB beta mediate different NFkB responses. IkB alpha appears to control more transient activation of NFkB in response to an inducer, while IKB beta controls a persistent response. Bcl3 interacts with p50 and p52 containing forms of NFkB, but rather than being an inhibitor it appears to function to stimulate transcription. The degradation of IKB is confirmed by immunoblotting.