|
| |
| Cat. No |
Model |
Description |
Unit |
Price
(VAT별도) |
납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-352111 |
NBP1-03433 |
AKT1 [phospho Ser473] Antibody//Human, Mouse,/Sheep |
1/EA |
|
|
|
|
문의 |
|
|
|
|
|
|
|
Subject
|
AKT1 [phospho Ser473] Antibody |
|
Description
|
/ Human, Mouse,/Sheep |
|
Clonality
|
Poly |
|
Company
|
Novus biologicals |
|
Application
|
IHC-P, Western Blot |
|
Conjugation
|
|
|
Immunogen
|
|
|
Contents
|
Description:Summary: | Species: | Hu, Rt, Mu | | Applications: | WB, IHC | | Clonality: | Polyclonal | | | Gene: | AKT1 | | Purity: | Whole antisera | | Host: | Sheep | | | Specificity: | AKT1, AKT2, AKT3. NBP1-03433 is also very likely to recognise the unphosphorylated form. | | Publications: | Antibody has not yet been mentioned in a publication. | Details: | Modification: | phospho Ser473 | | Immunogen: | A synthetic peptide from the phospho S473 c-terminal of AKT (RAC-alpha serine/threonine-protein kinase, PKB, RAC) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat, human and chicken AKT1. | | Localization: | subcellular location: cytoplasm. nucleus. cell membrane. note: nucleus after activation by integrin-linked protein kinase 1 (ilk1). nuclear translocation is enhanced by interaction with tcl1a.; tissue specificity: widely expressed. low levels found in liv | Gene Symbol: AKT1 | Entrez: | 207 (Human) | | | 11651 (Mouse) | | | 24185 (Rat) | | | P31750 (Mouse) | | Related Genes: | PIK3CG, PTK2B, MAPK1, PIK3CA, PIK3CB, PIK3CD, MAPK3, EPHB2, INS, MTOR, EGFR, PTEN, CASP3, VEGFA, INSR, MAPK8, EGF, MAPK12, NFKB1, MAPK14, GRAP2, AHSA1, AIMP2, SLC2A4, CDC42, SRC, BCL2L1, BCL2, NOS3, RHO, RHOD, CDKN1A, IRS1, TNF, ERBB2, PSMC4, JUN, PTK2, FOXO1, IRS-1 | Background: General protein kinase capable of phosphorylating several known proteins. phosphorylates tbc1d4. signals downstream of phosphatidylinositol 3-kinase (pi(3)k) to mediate the effects of various growth factors such as platelet-derived growth factor (pdgf), epidermal growth factor (egf), insulin and insulin-like growth factor i (igf-i). plays a role in glucose transport by mediating insulin-induced translocation of the glut4 glucose transporter to the cell surface. mediates the antiapoptotic effects of igf-i. mediates insulin-stimulated protein synthesis, partly by playing a role in both insulin-induced phosphorylation of 4e-bp1 and in insulin-induced activation of p70 s6 kinase. promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. Species: | Reactivity: | Reacts with Mouse, Rat, Human. | Applications: | Uses: | This antibody is useful for Immunohistochemistry and Western Blot. | | Dilutions: | immunohistochemistry, Western Blot 1:300-1:2000, | Notes: Reconstitute in 0.1 ml of sterile water. Centrifuge to remove any insoluble material. When reconstituting, glycerol (1:1) may be added for an additional stability. Packaging: | Buffer: | Lyophilized | | Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. | | Preservative: | No Preservative | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
|
|
|
|
