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Description |
Unit |
Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-352144 |
NB110-96893 |
AKT2 Antibody//Bovine, Canine/Rabbit |
1/EA |
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문의 |
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Subject
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AKT2 Antibody |
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Description
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/ Bovine, Canine/Rabbit |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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ELISA, Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Xp, Sh, GP, Rb, Rt, Mk, Po, Mu, Hu, Ha, Ch, Ca, Bv | | Applications: | ELISA, WB | | Clonality: | Polyclonal | | | Gene: | AKT2 | | Purity: | Affinity purified | | Host: | Rabbit | | | Specificity: | Detects an approx. 65kDa protein, corresponding to the molecular mass of Akt2 PKB beta on SDSPAGE immunoblots. Does not react with PKB alpha (Akt1) or PKB gamma (Akt3). | | Publications: | Antibody has not yet been mentioned in a publication. | Details: | Immunogen: | A five residue synthetic peptide based on the human Akt2, coupled to KLH | Gene Symbol: AKT2 | Entrez: | 208 (Human) | | | 11652 (Mouse) | | | 25233 (Rat) | | Related Genes: | AKT1, PIK3CG, PTK2B, AKT3, INS, PIK3CA, PIK3CB, PIK3CD, SLC2A4, INSR, PTEN, MTOR, ERBB2, EGFR, MAPK1, EGF, PLEK, IRS1, TP53, IRS-1, EPHB2, PPARG, PDK1, PDPK1, CASP3, MAPK3, MAPK8, TBC1D4, MED10, TM4SF1, CDKN2A, PIK3R1, INPPL1, MYC, ARHGEF7, HGF, SLC2A1, MAPK14, PIK3R2, MMP9 | Background: Protein kinase B or Akt (PKB/Akt) is a serine/threonine kinase, which in mammals comprises three highly homologous members known as PKB alpha (Akt1), PKB beta (Akt2) and PKB gamma (Akt3). PKB/Akt is a growth factor regulated protein kinase which contains a Pleckstrin Homology (PH) domain which might be important for dimerization of the kinase. Binding of phosphoinositide 3-OH kinase products to the pleckstrin homology domain results in translocation of PKB/Akt to the plasma membrane where it is activated by phosphorylation by upstream kinases including the phosphoinoside-dependent kinase 1 (PDK1) and PDK2 (1-3). Myelin basic protein and histone H2B are in vitro substrates for PKB, while glycogen synthase kinase-3 has been implicated as a physiological target (4). Key roles for this enzyme can be found in cellular processes such as glucose metabolism, cell proliferation, apoptosis, transcription and cell migration (1-3). Species: | Reactivity: | Cross reacts with Human, Mouse, Rat, Bovine, Chicken, Dog, Guinea pig, Hamster, Monkey, Pig, Rabbit, Sheep and Xenopus. | Applications: | Uses: | ELISA and Western Blot | | Dilutions: | ELISA , Western Blot 13000 | | Concentrations: | 0.25 mg/ml | | Positive Controls: | 1 positive controls | Packaging: | Buffer: | 0.1M Tris-acetate buffer | | Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. | | Preservative: | 0.1% Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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