| Synonyms | GRB2-associated-binding protein 1; GRB2-associated binder 1 |
| Swiss Prot Num | Q13480 |
| Immunogen | This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y659 of human Gab1. |
| Product Type | Antibodies |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| References | 1. Podar, K., et al., J. Biol. Chem. 279(20):21658-21665 (2004). 2. Ren, Y., et al., J. Biol. Chem. 279(9):8497-8505 (2004). 3. Kapoor, G.S., et al., Mol. Cell. Biol. 24(2):823-836 (2004). 4. Nakaoka, Y., et al., Circ. Res. 93(3):221-229 (2003). 5. Holgado-Madruga, M., et al., Mol. Cell. Biol. 23(13):4471-4484 (2003). |
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| Format | State: Liquid purified Ig fraction. |
| ? | Purification: Protein A Affinity Chromatography. Then, the antibody fraction is peptide affinity purified in a 2-step procedure with peptides. The antibody is eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| ? | Buffer System: PBS with 0.09% (W/V) Sodium Azide as preservative. |
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| Specificity | This antibody detects Gab1 pTyr659. Predicted to cross react with Mouse (100% Antigen Homology). |
| Add. information | Molecular weight: 76485 Da |
| Application | ELISA: 1/1,000. Dot Blot: 1/100-1/500. |
| Background | Gab1 is a member of the IRS1-like multisubstrate docking protein family. This protein is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. |
| Caution | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Concentration | 0.25 mg/ml |
