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Description |
Unit |
Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-24-372759 |
AP12617PU-N |
Gab1 Mutant//Human/Rabbit |
1/EA |
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Subject
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Gab1 Mutant |
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Description
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/ Human/Rabbit |
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Clonality
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Mono |
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Company
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Acris Antibodies GmbH |
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Application
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Enzyme Immunoassay, Paraffin Sections |
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Conjugation
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Immunogen
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Contents
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Description: | Manufacturer | Acris Antibodies GmbH | | Quantity | 0.1 mg | | Reactivity | Human | | Presentation | Purified | | Applications | Enzyme Immunoassay, Paraffin Sections | | Isotype | Ig | | Host | Rabbit | | Shipping to | Worldwide | | Synonyms | GRB2-associated-binding protein 1; GRB2-associated binder 1; GAB1; | | Swiss Prot Num | Q13480 | | Immunogen | This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding Y659 of human GAB1 Y659. | | Product Type | Antibodies | | Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. | | References | 1. Podar, K., et al., J. Biol. Chem. 279(20):21658-21665 (2004). 2. Ren, Y., et al., J. Biol. Chem. 279(9):8497-8505 (2004). 3. Kapoor, G.S., et al., Mol. Cell. Biol. 24(2):823-836 (2004). 4. Nakaoka, Y., et al., Circ. Res. 93(3):221-229 (2003). 5. Holgado-Madruga, M., et al., Mol. Cell. Biol. 23(13):4471-4484 (2003). | |
| Format | State: Liquid purified Ig fraction. | | ? | Purification: Protein A Chromatography, followed by peptide affinity purification. | | ? | Buffer System: PBS with 0.09% (W/V) Sodium Azide as preservative. | |
| Specificity | This antibody detects Gab1 Mutant pTyr659 | | Add. information | Molecular weight: 76616 Da | | Application | ELISA: 1/1,000. Immunohistochemistry: 1/50-1/100. | | Background | The Grb2-associated binder 1 (Gab1) is a multisubstrate scaffold/adapter protein that contains a pleckstrin homology domain at the NH2 terminus and multiple tyrosyl residues and proline-rich motifs for association with src homology 2 (SH2)-containing and SH3-containing proteins. Gab1, as well as its close relatives Gab2 and Gab3, serves to couple signaling between cell surface receptors for growth factors and cytokines with a variety of downstream targets, including Shp2 tyrosine phosphatase, phosphatidylinositol 3-kinase (PI3K), and phospholipase C-gamma. Ablation of the Gab1 gene in mice resulted in embryonic death in homozygous mutants, with developmental defects in the placenta, heart, and skin. Biochemical analysis of Gab1-/- fibroblast cells suggested a positive role of Gab1 in coupling the signal relay between cytokine receptors and the ERK pathway. | | Caution | This product is for research use only. Not for use in diagnostic or therapeutic procedures. | | Concentration | 0.25 mg/ml | |
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