| Synonyms | Review 022 |
| Swiss Prot Num | P63079 |
| Immunogen | Fusion protein within the cytosolic loop of rat GABA A receptor beta 3 subunit. |
| Product Type | Antibodies |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| References | 1. Burt, D.R. et al. (1991) GABAA receptor subtypes: from pharmacology to molecular biology. FASEB. J. 5: 2916 - 2923. |
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| Format | State: Liquid purified Ig |
| ? | Purification: Affinity chromatography |
| ? | Buffer System: 10mM HEPES pH7.5 containing 0.09% Sodium Azide, 0.01% Bovine Serum Albumin and 50% Glycerol |
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| Specificity | This antibody is specific for the beta 3 subunit of gamma-aminobutyric acid A (GABA A) receptor. |
| Application | Western Blot: 1:1000; detects a band of approximately 53 kDa in cerebellum lysates. |
| Background | GABA A receptors are GABA gated chloride channels, which are important mediators of neuronal inhibition in the mammalian central nervous system. Activation of the GABA A site results in increased intracellular chloride concentration and hyperpolarization of the cell. GABA A receptors are pentameric structures assembled from a family of distinct subunits. At least fourteen distinct subunits have been identified, which show distinct patterns of temporal and spatial expression. GABA A receptors may be modulated by several drug types including benzodiazepines and barbiturates, and by phosphorylation by protein kinase C (PKC) and protein kinase A (PKA). |
| Caution | (A full Health and Safety assessment is available upon request) This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only. |
| Review | r022 GABA A Receptor Regulator of Excitability and Drug Ta |
