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Subject
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JAB1 |
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Description
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/ Human, Mouse, Rat/Rabbit |
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Clonality
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Mono |
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Company
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Acris Antibodies GmbH |
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Application
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Paraffin Sections, Western blot / Immunoblot |
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Conjugation
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Immunogen
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Contents
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Description: | Manufacturer | Acris Antibodies GmbH | | Quantity | 1.0 ml | | Reactivity | Human, Mouse, Rat | | Presentation | Purified | | Applications | Paraffin Sections, Western blot / Immunoblot | | Host | Rabbit | | PDF datasheet | view | | Shipping to | Worldwide | | Swiss Prot Num | Q92905 | | Immunogen | Synthetic peptide from N-terminal of human JAB1 protein | | Product Type | Antibodies | | Storage | Store the antibody (undiluted) at 2 – 8 °C. Shelf life: One year from despatch. | |
| Format | State: Liquid affinity purified Ig fraciton | | ? | Buffer System: 10 mM PBS, pH 7.4 with BSA and Sodium Azide | |
| Specificity | This antibody detects JAB1 at N-term. | | Add. information | Molecular weight: 38 kDa. | | Application | Immunohistochemistry on Paraffin Sections (1:200, 30 min at RT), staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min. Positive control: Breast Carcinoma. | | Background | Jun activation domain-binding protein-1 (JAB1) also designated COP9 subunits 5 (COPS5) or SGN5 is a coactivator of AP-1 transcription factor that also promotes degradation of the cyclin-dependent kinase inhibitor p27Kip1. JAB1 interacts with c-Jun AP-1 containing complexes, and enhances transactivation from AP-1-dependent promoters. JAB1 is highly conserved in evolution and is widely expressed in mammalian tissues. It is localized both the nucleus and the cytoplasm. | | Concentration | 0.2 mg/ml | |
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