| Synonyms | hGK-1, hK2, FocusOn006 |
| Immunogen | Line tumor cells expressing Human Kallikrein 2. |
| Product Type | Antibodies |
| Recommended Isotype Control | SM10P (for use in human samples), AM03095PU-N |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| References | 1. Fisher TL (2002): Generation of monoclonal antibodies specific for human kallikrein 2 (hK2) using hK2-expressing tumors. Prostate, 51(3):153-65. |
|
| Format | State: Liquid purified Ig fraction. |
| ? | Purification: Affinity Chromatography on Protein G. |
| ? | Buffer System: PBS containing 0.09% Sodium Azide as preservative. |
|
| Specificity | This antibody reacts with Kallikrein 2 and no detectable reactivity with PSA. |
| Application | ELISA. Immunocytochemistry. Protein Purification using Column Chromatography. Immunohistochemistry on Paraffin Embedded Sections: as a guideline, use antibody at 18 µg/ml. Perform heat mediated antigen retrieval (microwave method). |
| Background | Kallikreins (KLKs) are a subgroup of trypsin-like serine proteases and are implicated in carcinogenesis. Kallikrein 2 is most closely related to Kallikrein 3 (PSA), with 78% identity and with kallikrein 1, at 68% identity. Like Kallikrein 3, Kallikrein 2 is found in greatest abundance in the prostate, but at much lower levels than Kallikrein 3. In addition, Kallikrein 2 seems to be more labile than Kallikrein 1 or Kallikrein 3 and is often found in a cleaved form. Kallikrein 2 is inhibited by Protein C Inhibitor (PCI). |
| Concentration | 1.0 mg/ml |
| Focuson | 006 Antibodies to Kallikrein Family |
