|
| |
| Cat. No |
Model |
Description |
Unit |
Price
(VAT별도) |
납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-375754 |
BM4008F |
F4/80 Antibody (A3-1 (F4/80))//Mouse/Rat |
1/EA |
|
|
|
|
문의 |
|
|
|
|
|
|
|
Subject
|
F4/80 Antibody (A3-1 (F4/80)) |
|
Description
|
/ Mouse/Rat |
|
Clonality
|
Mono |
|
Company
|
Novus biologicals |
|
Application
|
FACS |
|
Conjugation
|
|
|
Immunogen
|
|
|
Contents
|
Description:Summary: | Species: | Mu | | Applications: | FACS | | Clonality: | Monoclonal | | | Gene: | EMR1 | | Purity: | protein G purified | | Host: | Rat | | | Specificity: | This antibody recognises the F4/80 antigen, a member of the EGF-TM7 family of proteins which shares 68% overall amino acid identity with human EGF module-containing mucin-like hormone receptor 1 (EMR1). Clone CI:A3-1 has been reported to modulate cytokine levels released in response to Listeria monocytogenes. | | Publications: | Antibody has not yet been mentioned in a publication. | Details: | Clone: | A3-1 (F4/80) | | Isotype: | IgG2b | | Immunogen: | Thioglycollate stimulated peritoneal cavity macrophages from C57/BL mice. | Gene Symbol: EMR1 | Entrez: | 2015 (Human) | | Related Genes: | Cd97, Egf, Egf, Emr1, EGF, Cd97, CD97, Emr4, Cd55, CD55, Cd55, EMR2, Tnf, Cd68, Emr4p, Cd68, Eltd1, INS, EMR4P, Tnf, CD68, Ccl2, Ccl2, IL6, CCL2, Il6, Il6, TNF, EMR3, GPR151, Sct, Ccl3, PPARG, IL1B, Nos2, Fcgr3, MRGPRX1, IL8, FCGR3B, FCGR3A | Background: F4/80 is a 160 kD cell surface glycoprotein that is a member of the EGFTM7 family of proteins which shares 68% overall amino acid identity with human EGF module-containing mucinlike hormone receptor 1 (EMR1). Expression of F4/80 is heterogeneous and is reported to vary during macrophage maturation and activation. The F4/80 antigen is expressed on a wide range of mature tissue macrophages including Kupffer cells, Langerhans, microglia, macrophages located in the gut lamina propria, peritoneal cavity, lung, thymus, bone marrow stroma and macrophages in the red pulp of the spleen. F4/80 expression has also been reported on a subpopulation of dendritic cells but is absent from macrophages located in T cell areas of the spleen and lymph node. The ligands and biological functions of the F4/80 antigen have not yet been determined but recent studies suggest a role for F4/80 in the generation of efferent CD8+ve regulatory T cells. Species: Applications: | Uses: | Flow cytometry / FACS analysis | | Dilutions: | flow cytometry / FACS analysis | | Concentrations: | 0.1 mg/ml | Packaging: | Buffer: | PBS, pH 7.4 and 1% Bovine Serum Albumin | | Storage: | Store at 4C. Do not freeze. | | Preservative: | 0.09% Sodium Azide | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
|
|
|
|
