Synonyms | Prostate-Specific Antigen, Semenogelase, Seminin, APS, P-30 Antigen, FocusOn006 |
Swiss Prot Num | P07288 |
Immunogen | Purified prostate specific antigen |
Product Type | Antibodies |
Recommended Isotype Control | SM10P (for use in human samples), AM03095PU-N |
Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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Format | State: Liquid purified Ig |
? | Purification: Affinity chromatography on Protein A |
? | Buffer System: PBS, pH 7.4 containing 0.04% Sodium Azide |
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Specificity | This antibody is specific for prostate specific antigen (PSA) (capture). |
Application | ELISA: This antibody is recommended as a capture antibody in PSA sandwich assay along with AM01214PU-N anti-PSA (detection). |
Background | PSA is a 34 kDa member of the Kallikrein subfamily that is secreted in seminal plasma. PSA hydrolyses the seminal vesicle protein, semenogelin-1, which causes the liquefaction of the seminal coagulum. Tumour cell migration is promoted by PSA, furthering the progression of prostate cancer. Latent TGFbeta2 is activated in a process involving PSA, which may contribute to the formation of osteoblastic lesions in bone metastatic prostate cancer. Serum levels of PSA are important in the diagnosis and monitoring of prostatic carcinoma. In addition, levels of PSA in nipple aspirate fluid maybe useful in breast cancer detection. |
Concentration | 1.0mg/ml |
Focuson | 006 Antibodies to Kallikrein Family |